The Association Between Elevated Progesterone Level on Day of hCG Trigger and Live Birth Rates in ART Cycles: A Single Centre Observational Study
The advent of ovarian stimulation within an fertilization (IVF) cycle has resulted in modifying the physiology of stimulated cycles and has helped optimize pregnancy outcomes. In this regard, the importance of progesterone (P4) elevation at time of human chorionic gonadotrophin (hCG) administration...
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| Veröffentlicht in: | Faṣlnāmah-i pizishkī-i bārvar va nābārvar 2020-10, Vol.21 (4), p.283-290 |
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| container_title | Faṣlnāmah-i pizishkī-i bārvar va nābārvar |
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| creator | Robati, Shahin Saab, Wiam Durán-Retamal, Montserrat Saab, Wael Theodorou, Efstathios Cawood, Suzanne Serhal, Paul Seshadri, Srividya |
| description | The advent of ovarian stimulation within an
fertilization (IVF) cycle has resulted in modifying the physiology of stimulated cycles and has helped optimize pregnancy outcomes. In this regard, the importance of progesterone (P4) elevation at time of human chorionic gonadotrophin (hCG) administration within an IVF cycle has been studied over several decades. Our study aimed to evaluate the association of P4 levels at time of hCG trigger with live birth rate (LBR), clinical pregnancy rate (CPR) and miscarriage rate (MR) in fresh IVF or IVF-ICSI cycles.
This was a retrospective cohort study (n=170) involving patients attending the Centre for Reproductive and Genetic Health (CRGH) in London. The study cohort consisted of women undergoing controlled ovarian stimulation using GnRH antagonist or GnRH agonist protocols. Univariate and multiple logistic regression analyses were used to evaluate the association of clinical outcomes. Differences were considered statistically significant if p≤0.05.
As serum progesterone increased, a decrease in LBR was observed. Following multivariate logistical analyses, LBR significantly decreased with P4 thresholds of 4.0
(OR 0.42, 95% CI:0.17-1.0) and 4.5
(OR 0.35, 95% CI:0.12-0.96).
P4 levels are important in specific groups and the findings were statistically significant with a P4 threshold value between 4.0-4.5
. Therefore, it seems logical to selectively measure serum P4 levels for patients who have ovarian dysfunction or an ovulatory cycles and accordingly prepare the individualized management packages for such patients. |
| doi_str_mv | 10.18502/jri.v21i4.4333 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7648872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A643531217</galeid><sourcerecordid>A643531217</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4343-a1382b431ac2c6441e0fcc7bb5cbdf5931c3dae77fd7cec3e845e68e866e457c3</originalsourceid><addsrcrecordid>eNptks1u1DAUhSMEolXpmh2yhITYZBr_JHFYIE1DKUgjFbWDxM5ynJvEI0_c2knQPAZvjDMtpYOwF7bs7xzb1yeKXuNkgXmakLON04uJYM0WjFL6LDomJMVxlmc_ns9zwuOUcXIUnXq_SUIrCkxo8TI6opQkRc7S4-jXugO09N4qLQdte3QOw0-AHl0YmOQANfrmbAt-AGd7QCuYwKCAfZI7ZBvUlZdo7XTbgkOyr9FKT4DOtRs6dB3UHukeLa_XqNwpA_4DWqIb3bcGUAn94ABdVR7ctD9ZGnQzjPXuVfSikcbD6cN4En3_fLEuv8Srq8uv5XIVK0YZjSWmnFSMYqmIyhjDkDRK5VWVqqpu0oJiRWsJed7UuQJFgbMUMg48y4CluaIn0cd739ux2kKt5gtJI26d3kq3E1ZqcbjT6060dhJ5xjjPSTB4_2Dg7N0YSiS22iswRvZgRy8IywjDCU2SgL79B93Y0YUnByoLSMExp3-pVhoQum9sOFfNpmKZMZpSTHAeqMV_qNBr2GoVPqnRYf1A8O6JoANphs5bM85F94fg2T2onPXeQfNYDJyIfeJESJzYJ07MiQuKN09r-Mj_yRf9De-K0Rs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2610398183</pqid></control><display><type>article</type><title>The Association Between Elevated Progesterone Level on Day of hCG Trigger and Live Birth Rates in ART Cycles: A Single Centre Observational Study</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Robati, Shahin ; Saab, Wiam ; Durán-Retamal, Montserrat ; Saab, Wael ; Theodorou, Efstathios ; Cawood, Suzanne ; Serhal, Paul ; Seshadri, Srividya</creator><creatorcontrib>Robati, Shahin ; Saab, Wiam ; Durán-Retamal, Montserrat ; Saab, Wael ; Theodorou, Efstathios ; Cawood, Suzanne ; Serhal, Paul ; Seshadri, Srividya</creatorcontrib><description>The advent of ovarian stimulation within an
fertilization (IVF) cycle has resulted in modifying the physiology of stimulated cycles and has helped optimize pregnancy outcomes. In this regard, the importance of progesterone (P4) elevation at time of human chorionic gonadotrophin (hCG) administration within an IVF cycle has been studied over several decades. Our study aimed to evaluate the association of P4 levels at time of hCG trigger with live birth rate (LBR), clinical pregnancy rate (CPR) and miscarriage rate (MR) in fresh IVF or IVF-ICSI cycles.
This was a retrospective cohort study (n=170) involving patients attending the Centre for Reproductive and Genetic Health (CRGH) in London. The study cohort consisted of women undergoing controlled ovarian stimulation using GnRH antagonist or GnRH agonist protocols. Univariate and multiple logistic regression analyses were used to evaluate the association of clinical outcomes. Differences were considered statistically significant if p≤0.05.
As serum progesterone increased, a decrease in LBR was observed. Following multivariate logistical analyses, LBR significantly decreased with P4 thresholds of 4.0
(OR 0.42, 95% CI:0.17-1.0) and 4.5
(OR 0.35, 95% CI:0.12-0.96).
P4 levels are important in specific groups and the findings were statistically significant with a P4 threshold value between 4.0-4.5
. Therefore, it seems logical to selectively measure serum P4 levels for patients who have ovarian dysfunction or an ovulatory cycles and accordingly prepare the individualized management packages for such patients.</description><identifier>ISSN: 2228-5482</identifier><identifier>ISSN: 1726-7536</identifier><identifier>EISSN: 2251-676X</identifier><identifier>DOI: 10.18502/jri.v21i4.4333</identifier><identifier>PMID: 33209745</identifier><language>eng</language><publisher>Iran: Avicenna Research Institute</publisher><subject>Analysis ; Birth rate ; Evaluation ; Gonadotropin-releasing hormone ; In vitro fertilization ; Medical research ; Observational studies ; Original ; Ovaries ; Patients ; Pituitary (anterior) ; Placental hormones ; Pregnancy ; Progesterone ; Regression analysis ; Statistical analysis ; Stimulation</subject><ispartof>Faṣlnāmah-i pizishkī-i bārvar va nābārvar, 2020-10, Vol.21 (4), p.283-290</ispartof><rights>Copyright© 2020, Avicenna Research Institute.</rights><rights>COPYRIGHT 2020 Avicenna Research Institute</rights><rights>Copyright Office for Scientific Journals 2020</rights><rights>Copyright© 2020, Avicenna Research Institute. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4343-a1382b431ac2c6441e0fcc7bb5cbdf5931c3dae77fd7cec3e845e68e866e457c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648872/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648872/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33209745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robati, Shahin</creatorcontrib><creatorcontrib>Saab, Wiam</creatorcontrib><creatorcontrib>Durán-Retamal, Montserrat</creatorcontrib><creatorcontrib>Saab, Wael</creatorcontrib><creatorcontrib>Theodorou, Efstathios</creatorcontrib><creatorcontrib>Cawood, Suzanne</creatorcontrib><creatorcontrib>Serhal, Paul</creatorcontrib><creatorcontrib>Seshadri, Srividya</creatorcontrib><title>The Association Between Elevated Progesterone Level on Day of hCG Trigger and Live Birth Rates in ART Cycles: A Single Centre Observational Study</title><title>Faṣlnāmah-i pizishkī-i bārvar va nābārvar</title><addtitle>J Reprod Infertil</addtitle><description>The advent of ovarian stimulation within an
fertilization (IVF) cycle has resulted in modifying the physiology of stimulated cycles and has helped optimize pregnancy outcomes. In this regard, the importance of progesterone (P4) elevation at time of human chorionic gonadotrophin (hCG) administration within an IVF cycle has been studied over several decades. Our study aimed to evaluate the association of P4 levels at time of hCG trigger with live birth rate (LBR), clinical pregnancy rate (CPR) and miscarriage rate (MR) in fresh IVF or IVF-ICSI cycles.
This was a retrospective cohort study (n=170) involving patients attending the Centre for Reproductive and Genetic Health (CRGH) in London. The study cohort consisted of women undergoing controlled ovarian stimulation using GnRH antagonist or GnRH agonist protocols. Univariate and multiple logistic regression analyses were used to evaluate the association of clinical outcomes. Differences were considered statistically significant if p≤0.05.
As serum progesterone increased, a decrease in LBR was observed. Following multivariate logistical analyses, LBR significantly decreased with P4 thresholds of 4.0
(OR 0.42, 95% CI:0.17-1.0) and 4.5
(OR 0.35, 95% CI:0.12-0.96).
P4 levels are important in specific groups and the findings were statistically significant with a P4 threshold value between 4.0-4.5
. Therefore, it seems logical to selectively measure serum P4 levels for patients who have ovarian dysfunction or an ovulatory cycles and accordingly prepare the individualized management packages for such patients.</description><subject>Analysis</subject><subject>Birth rate</subject><subject>Evaluation</subject><subject>Gonadotropin-releasing hormone</subject><subject>In vitro fertilization</subject><subject>Medical research</subject><subject>Observational studies</subject><subject>Original</subject><subject>Ovaries</subject><subject>Patients</subject><subject>Pituitary (anterior)</subject><subject>Placental hormones</subject><subject>Pregnancy</subject><subject>Progesterone</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Stimulation</subject><issn>2228-5482</issn><issn>1726-7536</issn><issn>2251-676X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1u1DAUhSMEolXpmh2yhITYZBr_JHFYIE1DKUgjFbWDxM5ynJvEI0_c2knQPAZvjDMtpYOwF7bs7xzb1yeKXuNkgXmakLON04uJYM0WjFL6LDomJMVxlmc_ns9zwuOUcXIUnXq_SUIrCkxo8TI6opQkRc7S4-jXugO09N4qLQdte3QOw0-AHl0YmOQANfrmbAt-AGd7QCuYwKCAfZI7ZBvUlZdo7XTbgkOyr9FKT4DOtRs6dB3UHukeLa_XqNwpA_4DWqIb3bcGUAn94ABdVR7ctD9ZGnQzjPXuVfSikcbD6cN4En3_fLEuv8Srq8uv5XIVK0YZjSWmnFSMYqmIyhjDkDRK5VWVqqpu0oJiRWsJed7UuQJFgbMUMg48y4CluaIn0cd739ux2kKt5gtJI26d3kq3E1ZqcbjT6060dhJ5xjjPSTB4_2Dg7N0YSiS22iswRvZgRy8IywjDCU2SgL79B93Y0YUnByoLSMExp3-pVhoQum9sOFfNpmKZMZpSTHAeqMV_qNBr2GoVPqnRYf1A8O6JoANphs5bM85F94fg2T2onPXeQfNYDJyIfeJESJzYJ07MiQuKN09r-Mj_yRf9De-K0Rs</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Robati, Shahin</creator><creator>Saab, Wiam</creator><creator>Durán-Retamal, Montserrat</creator><creator>Saab, Wael</creator><creator>Theodorou, Efstathios</creator><creator>Cawood, Suzanne</creator><creator>Serhal, Paul</creator><creator>Seshadri, Srividya</creator><general>Avicenna Research Institute</general><general>Office for Scientific Journals</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>The Association Between Elevated Progesterone Level on Day of hCG Trigger and Live Birth Rates in ART Cycles: A Single Centre Observational Study</title><author>Robati, Shahin ; 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fertilization (IVF) cycle has resulted in modifying the physiology of stimulated cycles and has helped optimize pregnancy outcomes. In this regard, the importance of progesterone (P4) elevation at time of human chorionic gonadotrophin (hCG) administration within an IVF cycle has been studied over several decades. Our study aimed to evaluate the association of P4 levels at time of hCG trigger with live birth rate (LBR), clinical pregnancy rate (CPR) and miscarriage rate (MR) in fresh IVF or IVF-ICSI cycles.
This was a retrospective cohort study (n=170) involving patients attending the Centre for Reproductive and Genetic Health (CRGH) in London. The study cohort consisted of women undergoing controlled ovarian stimulation using GnRH antagonist or GnRH agonist protocols. Univariate and multiple logistic regression analyses were used to evaluate the association of clinical outcomes. Differences were considered statistically significant if p≤0.05.
As serum progesterone increased, a decrease in LBR was observed. Following multivariate logistical analyses, LBR significantly decreased with P4 thresholds of 4.0
(OR 0.42, 95% CI:0.17-1.0) and 4.5
(OR 0.35, 95% CI:0.12-0.96).
P4 levels are important in specific groups and the findings were statistically significant with a P4 threshold value between 4.0-4.5
. Therefore, it seems logical to selectively measure serum P4 levels for patients who have ovarian dysfunction or an ovulatory cycles and accordingly prepare the individualized management packages for such patients.</abstract><cop>Iran</cop><pub>Avicenna Research Institute</pub><pmid>33209745</pmid><doi>10.18502/jri.v21i4.4333</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Faṣlnāmah-i pizishkī-i bārvar va nābārvar, 2020-10, Vol.21 (4), p.283-290 |
| issn | 2228-5482 1726-7536 2251-676X |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Analysis Birth rate Evaluation Gonadotropin-releasing hormone In vitro fertilization Medical research Observational studies Original Ovaries Patients Pituitary (anterior) Placental hormones Pregnancy Progesterone Regression analysis Statistical analysis Stimulation |
| title | The Association Between Elevated Progesterone Level on Day of hCG Trigger and Live Birth Rates in ART Cycles: A Single Centre Observational Study |
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