Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Dopamine (DA) plays a critical role in the brain, and the ability to directly measure dopaminergic activity is essential for understanding its physiological functions. We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (GRAB DA ) sensors and optimized versions of g...

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Veröffentlicht in:	Nature methods 2020-11, Vol.17 (11), p.1156-1166
Hauptverfasser:	Sun, Fangmiao, Zhou, Jingheng, Dai, Bing, Qian, Tongrui, Zeng, Jianzhi, Li, Xuelin, Zhuo, Yizhou, Zhang, Yajun, Wang, Yipan, Qian, Cheng, Tan, Ke, Feng, Jiesi, Dong, Hui, Lin, Dayu, Cui, Guohong, Li, Yulong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1888/2249 631/1647/245/2226 631/378/340 631/378/548 Animals Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biosensing Techniques - methods Biosensors Brain Brain - metabolism Brain slice preparation Calcium Dopamine Dopamine - metabolism Dopamine receptors Drosophila - genetics Drosophila - metabolism Fluorescence Fruit flies G protein-coupled receptors G proteins Genetic code Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Health aspects HEK293 Cells Humans Life Sciences Luminescent Proteins - genetics Luminescent Proteins - metabolism Methods Mice Neural circuitry Neurological research Neurons - metabolism Neurotransmitters Physiological aspects Proteomics Rats Receptors, Dopamine - genetics Receptors, Dopamine - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Red Fluorescent Protein Sensors Sexual behavior Sexual Behavior - physiology
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