Complex roles of the actin‐binding protein Girdin/GIV in DNA damage‐induced apoptosis of cancer cells

The actin‐binding protein Girdin is a hub protein that interacts with multiple proteins to regulate motility and Akt and trimeric G protein signaling in cancer cells. Girdin expression correlates with poor outcomes in multiple human cancers. However, those findings are not universal, as they depend...

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Veröffentlicht in:	Cancer science 2020-11, Vol.111 (11), p.4303-4317
Hauptverfasser:	Chen, Chen, Enomoto, Atsushi, Weng, Liang, Taki, Tetsuro, Shiraki, Yukihiro, Mii, Shinji, Ichihara, Ryosuke, Kanda, Mitsuro, Koike, Masahiko, Kodera, Yasuhiro, Takahashi, Masahide
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Aged Aged, 80 and over AKT protein Animals Apoptosis Apoptosis - genetics Biomarkers Brain cancer Cancer cancer cell heterogeneity Cancer therapies Cell adhesion & migration Cell Cycle Cell growth Cell Line, Tumor cell migration CRISPR Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA Damage - radiation effects Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Neoplasms - radiotherapy Esophagus Female Genomes Girdin HeLa Cells Humans Kinases Male Microfilament Proteins - genetics Microfilament Proteins - metabolism Middle Aged Mitosis Models, Biological Neoplasm Grading Neoplasm Staging Neoplasms - genetics Neoplasms - metabolism Neoplasms - mortality Neoplasms - pathology Original p53 Protein Prognosis Proteins Reagents Stem cells Transcription activation Ultraviolet radiation Ultraviolet Rays Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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