Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial

Low‐dose methotrexate (MTX) plus vinblastine (VBL) chemotherapy is an effective treatment for desmoid‐type fibromatosis (DF). However, previous reports have described a weekly regimen, with no reports available on a biweekly one. The aim of this study was to determine the clinical outcomes of a biwe...

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Veröffentlicht in:	Cancer science 2020-11, Vol.111 (11), p.4187-4194
Hauptverfasser:	Nishida, Yoshihiro, Hamada, Shunsuke, Urakawa, Hiroshi, Ikuta, Kunihiro, Sakai, Tomohisa, Koike, Hiroshi, Ito, Kan, Emoto, Ryo, Ando, Yuichi, Matsui, Shigeyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use biweekly Chemotherapy Child Child, Preschool clinical benefit rate Consent desmoid Drug Administration Schedule Drug dosages Female Fibromatosis, Aggressive - diagnosis Fibromatosis, Aggressive - drug therapy Fibromatosis, Aggressive - mortality Follow-Up Studies Humans Kaplan-Meier Estimate Magnetic resonance imaging Male Methotrexate Methotrexate - administration & dosage Middle Aged Mutation Neoplasm Staging Original Patients Prognosis Proportional Hazards Models Regression analysis Surgery Treatment Outcome Tumors Vinblastine Vinblastine - administration & dosage Young Adult
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