miR‑124‑3p regulates angiogenesis in peripheral arterial disease by targeting STAT3

Peripheral arterial disease (PAD) is the third leading cause of cardiovascular morbidity worldwide, after coronary artery disease and stroke. As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer...

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Veröffentlicht in:	Molecular medicine reports 2020-12, Vol.22 (6), p.4890-4898
Hauptverfasser:	Shi, Yefei, Xu, Xu, Luan, Peipei, Kou, Wenxin, Li, Mingjie, Yu, Qing, Zhuang, Jianhui, Xu, Yawei, Peng, Wenhui, Jian, Weixia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiogenesis Angiogenesis Inducing Agents - metabolism Animals Ankle Autoimmune diseases Cell adhesion & migration Cell growth Cell Hypoxia - genetics Cell proliferation China Coronary artery Coronary artery disease Development and progression Disease Endothelial cells Female Gene expression Genetic aspects Growth factors Health aspects Heart diseases Hindlimb - blood supply Human Umbilical Vein Endothelial Cells - metabolism Humans Hypoxia Ischemia Ischemia - genetics Laboratories Male Medical research Mice MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Morbidity Morphogenesis Neovascularization Neovascularization, Pathologic - genetics Neovascularization, Physiologic - genetics Peripheral Arterial Disease - genetics Peripheral Arterial Disease - metabolism Peripheral vascular diseases Physiological aspects Proteins Reverse transcription Signal Transduction - physiology STAT3 Stat3 protein STAT3 Transcription Factor - metabolism STAT3 Transcription Factor - physiology Umbilical vein Wound healing
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