miR‑124‑3p regulates angiogenesis in peripheral arterial disease by targeting STAT3
Peripheral arterial disease (PAD) is the third leading cause of cardiovascular morbidity worldwide, after coronary artery disease and stroke. As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer...
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| Veröffentlicht in: | Molecular medicine reports 2020-12, Vol.22 (6), p.4890-4898 |
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| creator | Shi, Yefei Xu, Xu Luan, Peipei Kou, Wenxin Li, Mingjie Yu, Qing Zhuang, Jianhui Xu, Yawei Peng, Wenhui Jian, Weixia |
| description | Peripheral arterial disease (PAD) is the third leading cause of cardiovascular morbidity worldwide, after coronary artery disease and stroke. As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer, autoimmune diseases and heart diseases. In the present study, the role of miR‑124‑3p in PAD was investigated. The reverse transcription‑quantitative PCR results indicated that the expression levels of miR‑124‑3p were significantly increased in the ischemic tissue of the hindlimb ischemia (HLI) model and in hypoxic human umbilical vein endothelial cells compared with the corresponding control groups. Proliferation, wound healing and tube formation assays demonstrated the inhibition of miR‑124‑3p on angiogenesis in vitro and the HLI model indicated the same function of miR‑124‑3p in vivo. A dual‑luciferase reporter revealed STAT3 as the target of miR‑124‑3p. The expression levels of miR‑124‑3p in human blood were negatively correlated with ankle‑brachial index, which is an index for the evaluation of the severity of PAD. Collectively, the present study indicated that miR‑124‑3p was a critical regulator of angiogenesis in PAD, and a potential diagnostic, prognostic and therapeutic target for PAD. |
| doi_str_mv | 10.3892/mmr.2020.11538 |
| format | Article |
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As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer, autoimmune diseases and heart diseases. In the present study, the role of miR‑124‑3p in PAD was investigated. The reverse transcription‑quantitative PCR results indicated that the expression levels of miR‑124‑3p were significantly increased in the ischemic tissue of the hindlimb ischemia (HLI) model and in hypoxic human umbilical vein endothelial cells compared with the corresponding control groups. Proliferation, wound healing and tube formation assays demonstrated the inhibition of miR‑124‑3p on angiogenesis in vitro and the HLI model indicated the same function of miR‑124‑3p in vivo. A dual‑luciferase reporter revealed STAT3 as the target of miR‑124‑3p. The expression levels of miR‑124‑3p in human blood were negatively correlated with ankle‑brachial index, which is an index for the evaluation of the severity of PAD. Collectively, the present study indicated that miR‑124‑3p was a critical regulator of angiogenesis in PAD, and a potential diagnostic, prognostic and therapeutic target for PAD.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2020.11538</identifier><identifier>PMID: 33174610</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Aged ; Angiogenesis ; Angiogenesis Inducing Agents - metabolism ; Animals ; Ankle ; Autoimmune diseases ; Cell adhesion & migration ; Cell growth ; Cell Hypoxia - genetics ; Cell proliferation ; China ; Coronary artery ; Coronary artery disease ; Development and progression ; Disease ; Endothelial cells ; Female ; Gene expression ; Genetic aspects ; Growth factors ; Health aspects ; Heart diseases ; Hindlimb - blood supply ; Human Umbilical Vein Endothelial Cells - metabolism ; Humans ; Hypoxia ; Ischemia ; Ischemia - genetics ; Laboratories ; Male ; Medical research ; Mice ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Middle Aged ; miRNA ; Morbidity ; Morphogenesis ; Neovascularization ; Neovascularization, Pathologic - genetics ; Neovascularization, Physiologic - genetics ; Peripheral Arterial Disease - genetics ; Peripheral Arterial Disease - metabolism ; Peripheral vascular diseases ; Physiological aspects ; Proteins ; Reverse transcription ; Signal Transduction - physiology ; STAT3 ; Stat3 protein ; STAT3 Transcription Factor - metabolism ; STAT3 Transcription Factor - physiology ; Umbilical vein ; Wound healing</subject><ispartof>Molecular medicine reports, 2020-12, Vol.22 (6), p.4890-4898</ispartof><rights>COPYRIGHT 2020 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2020</rights><rights>Copyright: © Shi et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-dc74106b3b8da178cac84cb8defa9f2af95276ef96311ad11da412d16dc63ff53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33174610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Yefei</creatorcontrib><creatorcontrib>Xu, Xu</creatorcontrib><creatorcontrib>Luan, Peipei</creatorcontrib><creatorcontrib>Kou, Wenxin</creatorcontrib><creatorcontrib>Li, Mingjie</creatorcontrib><creatorcontrib>Yu, Qing</creatorcontrib><creatorcontrib>Zhuang, Jianhui</creatorcontrib><creatorcontrib>Xu, Yawei</creatorcontrib><creatorcontrib>Peng, Wenhui</creatorcontrib><creatorcontrib>Jian, Weixia</creatorcontrib><title>miR‑124‑3p regulates angiogenesis in peripheral arterial disease by targeting STAT3</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Peripheral arterial disease (PAD) is the third leading cause of cardiovascular morbidity worldwide, after coronary artery disease and stroke. As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer, autoimmune diseases and heart diseases. In the present study, the role of miR‑124‑3p in PAD was investigated. The reverse transcription‑quantitative PCR results indicated that the expression levels of miR‑124‑3p were significantly increased in the ischemic tissue of the hindlimb ischemia (HLI) model and in hypoxic human umbilical vein endothelial cells compared with the corresponding control groups. Proliferation, wound healing and tube formation assays demonstrated the inhibition of miR‑124‑3p on angiogenesis in vitro and the HLI model indicated the same function of miR‑124‑3p in vivo. A dual‑luciferase reporter revealed STAT3 as the target of miR‑124‑3p. The expression levels of miR‑124‑3p in human blood were negatively correlated with ankle‑brachial index, which is an index for the evaluation of the severity of PAD. Collectively, the present study indicated that miR‑124‑3p was a critical regulator of angiogenesis in PAD, and a potential diagnostic, prognostic and therapeutic target for PAD.</description><subject>Aged</subject><subject>Angiogenesis</subject><subject>Angiogenesis Inducing Agents - metabolism</subject><subject>Animals</subject><subject>Ankle</subject><subject>Autoimmune diseases</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Cell Hypoxia - genetics</subject><subject>Cell proliferation</subject><subject>China</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Endothelial cells</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Hindlimb - blood supply</subject><subject>Human Umbilical Vein Endothelial Cells - metabolism</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Ischemia</subject><subject>Ischemia - genetics</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Mice</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Morbidity</subject><subject>Morphogenesis</subject><subject>Neovascularization</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Neovascularization, Physiologic - genetics</subject><subject>Peripheral Arterial Disease - genetics</subject><subject>Peripheral Arterial Disease - metabolism</subject><subject>Peripheral vascular diseases</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Reverse transcription</subject><subject>Signal Transduction - physiology</subject><subject>STAT3</subject><subject>Stat3 protein</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>STAT3 Transcription Factor - physiology</subject><subject>Umbilical vein</subject><subject>Wound healing</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUk1v1DAQtRCIlsKVI4rEhctuPbbjxBekVQUUqRISLOJoee1x6ipxgp0g9cZf4C_yS_C2S_lQZWk8Y7954xk_Qp4DXfNWsdNhSGtGGV0D1Lx9QI6hUbDilIqHB58p1RyRJzlfUSprVqvH5IhzaIQEeky-DOHjz-8_gIli-VQl7JbezJgrE7swdhgxh1yFWE2YwnSJyfSVSXMJiuNCRpOx2l1Xs0kdziF21aftZsufkkfe9BmfHfYT8vntm-3Z-eriw7v3Z5uLlRVtPa-cbQRQueO71hloWmtsK2wJ0BvlmfGqZo1EryQHMA7AGQHMgXRWcu9rfkJe3_JOy25AZzHO5YV6SmEw6VqPJuh_b2K41N34TTdSSMV5IXh1IEjj1wXzrIeQLfa9iTguWTNRK8la0exrvfwPejUuKZb2CkqW6fIa2j-ozvSoQ_RjqWv3pHojBaeSFltQ63tQZTkcgh0j-lDO70uwacw5ob_rEajeS0EXKei9FPSNFErCi78ncwf__ff8F-HBsGk</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Shi, Yefei</creator><creator>Xu, Xu</creator><creator>Luan, Peipei</creator><creator>Kou, Wenxin</creator><creator>Li, Mingjie</creator><creator>Yu, Qing</creator><creator>Zhuang, Jianhui</creator><creator>Xu, Yawei</creator><creator>Peng, Wenhui</creator><creator>Jian, Weixia</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Yefei</au><au>Xu, Xu</au><au>Luan, Peipei</au><au>Kou, Wenxin</au><au>Li, Mingjie</au><au>Yu, Qing</au><au>Zhuang, Jianhui</au><au>Xu, Yawei</au><au>Peng, Wenhui</au><au>Jian, Weixia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR‑124‑3p regulates angiogenesis in peripheral arterial disease by targeting STAT3</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>22</volume><issue>6</issue><spage>4890</spage><epage>4898</epage><pages>4890-4898</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Peripheral arterial disease (PAD) is the third leading cause of cardiovascular morbidity worldwide, after coronary artery disease and stroke. As endogenous regulators of gene expression, microRNAs (miRs) are implicated in the development and progression of various diseases, including types of cancer, autoimmune diseases and heart diseases. In the present study, the role of miR‑124‑3p in PAD was investigated. The reverse transcription‑quantitative PCR results indicated that the expression levels of miR‑124‑3p were significantly increased in the ischemic tissue of the hindlimb ischemia (HLI) model and in hypoxic human umbilical vein endothelial cells compared with the corresponding control groups. Proliferation, wound healing and tube formation assays demonstrated the inhibition of miR‑124‑3p on angiogenesis in vitro and the HLI model indicated the same function of miR‑124‑3p in vivo. A dual‑luciferase reporter revealed STAT3 as the target of miR‑124‑3p. The expression levels of miR‑124‑3p in human blood were negatively correlated with ankle‑brachial index, which is an index for the evaluation of the severity of PAD. Collectively, the present study indicated that miR‑124‑3p was a critical regulator of angiogenesis in PAD, and a potential diagnostic, prognostic and therapeutic target for PAD.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>33174610</pmid><doi>10.3892/mmr.2020.11538</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Angiogenesis Angiogenesis Inducing Agents - metabolism Animals Ankle Autoimmune diseases Cell adhesion & migration Cell growth Cell Hypoxia - genetics Cell proliferation China Coronary artery Coronary artery disease Development and progression Disease Endothelial cells Female Gene expression Genetic aspects Growth factors Health aspects Heart diseases Hindlimb - blood supply Human Umbilical Vein Endothelial Cells - metabolism Humans Hypoxia Ischemia Ischemia - genetics Laboratories Male Medical research Mice MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Morbidity Morphogenesis Neovascularization Neovascularization, Pathologic - genetics Neovascularization, Physiologic - genetics Peripheral Arterial Disease - genetics Peripheral Arterial Disease - metabolism Peripheral vascular diseases Physiological aspects Proteins Reverse transcription Signal Transduction - physiology STAT3 Stat3 protein STAT3 Transcription Factor - metabolism STAT3 Transcription Factor - physiology Umbilical vein Wound healing |
| title | miR‑124‑3p regulates angiogenesis in peripheral arterial disease by targeting STAT3 |
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