Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy

COVID-19, the novel coronavirus pandemic, has already spread around the globe affecting more than 18 million people. As previously observed with other coronaviruses, SARS-CoV-2 deeply dysregulate the immune system eliciting respiratory failure and a state of systemic hyperinflammation in severely il...

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Veröffentlicht in:	Respiratory medicine 2020-12, Vol.175, p.106204-106204, Article 106204
Hauptverfasser:	Torre, Alessandro, Aliberti, Stefano, Castellotti, Paola Francesca, Cirillo, Daniela Maria, Grisolia, Antonella, Mangioni, Davide, Marchetti, Giulia, Rossotti, Roberto, Santus, Pierachille, Besozzi, Giorgio, Villa, Simone, Codecasa, Luigi Ruffo, Bandera, Alessandra, Blasi, Francesco, Campisi, Daniela, Ferrarese, Maurizio, Gramegna, Andrea, Lombardi, Alessandra, Mancon, Alessandro, Mantero, Marco, Muscatello, Antonio, Passerini, Matteo, Piscaglia, Marco, Saporiti, Matteo, Schiuma, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Anakinra Antibodies, Monoclonal, Humanized - therapeutic use Antirheumatic Agents - therapeutic use Cell number Chi-square test Coronaviridae Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - therapy COVID-19 - virology Cytokine-blocking agents Cytokines Drug dosages Editing Epidemiology Female Humans IGRA Immune response Immune system Immunity - physiology Immunosuppression - methods Immunosuppressive agents Immunotherapy Infections Interferon Interferon-gamma Release Tests - methods Interferon-gamma Release Tests - statistics & numerical data Interleukin 1 Receptor Antagonist Protein - therapeutic use Italy - epidemiology Latent Tuberculosis - diagnosis Latent Tuberculosis - epidemiology Latent Tuberculosis - immunology Latent Tuberculosis - prevention & control Lymphocytes Lymphopenia Lymphopenia - immunology Male Medical treatment Monoclonal antibodies Pandemics Patients Public health Respiratory failure Retrospective Studies SARS-CoV-2 - genetics Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Short Communication Statistical tests Supervision Tocilizumab Tuberculosis Viral infections Writing γ-Interferon
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