African Vegetables (Clerodendrum volibile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

Trastuzumab (TZM) is a humanized monoclonal antibody that has been approved for the clinical management of HER2-positive metastatic breast and gastric cancers but its use is limited by its cumulative dose and off-target cardiotoxicity. Unfortunately, till date, there is no approved antidote to this...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-15
Hauptverfasser:	Mukhtar, Hasan, Okoye, Ikechukwu, Mgbehoma, Alban, Soyemi, Sunday, Akinsola, Akinyele, Adeneye, Adejuwon, Olorundare, Olufunke, Ntambi, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Animals Antioxidants Autophagy Breast cancer Cardiomyocytes Cardiotoxicity Cardiotoxicity - drug therapy Cardiotoxicity - metabolism Cardiotoxicity - pathology Cardiovascular disease Cellulose - chemistry Clerodendrum - chemistry Cytotoxicity Enzymes Ethanol FDA approval Flavonoids Immunotherapy Lipids Male Metastasis Molybdenum alloys Monoclonal antibodies Plant Extracts - chemistry Plant Extracts - pharmacology Rats Rats, Wistar Seeds Seeds - chemistry Stomach cancer Targeted cancer therapy Trastuzumab - adverse effects Trastuzumab - pharmacology Vegetables
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