Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

Organogenesis is a complex and interconnected process that is orchestrated by multiple boundary tissue interactions 1 – 7 . However, it remains unclear how individual, neighbouring components coordinate to establish an integral multi-organ structure. Here we report the continuous patterning and dyna...

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Veröffentlicht in:	Nature (London) 2019-10, Vol.574 (7776), p.112-116
Hauptverfasser:	Koike, Hiroyuki, Iwasawa, Kentaro, Ouchi, Rie, Maezawa, Mari, Giesbrecht, Kirsten, Saiki, Norikazu, Ferguson, Autumn, Kimura, Masaki, Thompson, Wendy L., Wells, James M., Zorn, Aaron M., Takebe, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/106 13/107 631/136/2060 631/532/1360 631/61/2035 Acids Animals Bile ducts Biliary Tract - cytology Biliary Tract - embryology Biomarkers - analysis Biomarkers - metabolism Body Patterning Cell culture Cell differentiation Common bile duct Domains Endoderm Endoderm - cytology Endoderm - embryology Foregut Growth Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Intestines - cytology Intestines - embryology Letter Liver Liver - cytology Liver - embryology Male Mice Midgut Models, Biological Morphogenesis multidisciplinary Mutation Organogenesis Organoids Organoids - cytology Organoids - embryology Pancreas Pancreas - cytology Pancreas - embryology Pancreas transplantation Pancreatic islet transplantation Pattern formation Pluripotency Proteins Retinoic acid Science Science (multidisciplinary) Spheroids Spheroids, Cellular - cytology Spheroids, Cellular - metabolism Spheroids, Cellular - transplantation Stem cell transplantation Stem cells Transcription Factor HES-1 - analysis Transcription Factor HES-1 - metabolism
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