Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization and is nearly universal in EAC. TXNIP blocks glucose uptake and exhibits proapoptotic f...

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Veröffentlicht in:	Molecular cancer therapeutics 2018-09, Vol.17 (9), p.2013-2023
Hauptverfasser:	Feingold, Paul L, Surman, Deborah R, Brown, Kate, Xu, Yuan, McDuffie, Lucas A, Shukla, Vivek, Reardon, Emily S, Crooks, Daniel R, Trepel, Jane B, Lee, Sunmin, Lee, Min-Jung, Gao, Shaojian, Xi, Sichuan, McLoughlin, Kaitlin C, Diggs, Laurence P, Beer, David G, Nancarrow, Derek J, Neckers, Leonard M, Davis, Jeremy L, Hoang, Chuong D, Hernandez, Jonathan M, Schrump, David S, Ripley, R Taylor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Apoptosis - genetics Benzamides - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cisplatin - administration & dosage DNA Damage Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Female Gene Expression Regulation, Neoplastic - drug effects Histone Deacetylase Inhibitors - pharmacology Humans Mice, Nude Pyridines - pharmacology Transcriptional Activation - drug effects Xenograft Model Antitumor Assays
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