Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption
Carbohydrate malabsorption and subsequent gastrointestinal symptoms are a common clinical problem in pediatrics. Hydrogen (H 2 ) and methane (CH 4 ) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well...
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| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.18972-18972, Article 18972 |
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| creator | Schneider, Christof Wutzke, Klaus D. Däbritz, Jan |
| description | Carbohydrate malabsorption and subsequent gastrointestinal symptoms are a common clinical problem in pediatrics. Hydrogen (H
2
) and methane (CH
4
) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well as the impact of non-hydrogen producers (NHP) is unclear. CH
4
breath tests (MBT), blood sugar tests (BST) and clinical symptoms were compared with H
2
breath tests (HBT) for FM/LM. 187/82 tests were performed in children (2 to 18 years) with unclear chronic/recurrent abdominal pain and suspected FM/LM. In FM and LM, we found a significant correlation between HBT and MBT/BST. In LM, MBT differentiated most of the patients correctly and BST might be used as an exclusion test. However, additional MBT and BST had no diagnostic advantage in FM. NHP still remain a group of patients, which cannot be identified using the recommended CH
4
cut-off values in FM or LM. Reported symptoms during breath tests are not a reliable method to diagnose FM/LM. Overall a combined test approach might help in diagnosing children with suspected carbohydrate malabsorption. |
| doi_str_mv | 10.1038/s41598-020-75987-6 |
| format | Article |
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2
) and methane (CH
4
) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well as the impact of non-hydrogen producers (NHP) is unclear. CH
4
breath tests (MBT), blood sugar tests (BST) and clinical symptoms were compared with H
2
breath tests (HBT) for FM/LM. 187/82 tests were performed in children (2 to 18 years) with unclear chronic/recurrent abdominal pain and suspected FM/LM. In FM and LM, we found a significant correlation between HBT and MBT/BST. In LM, MBT differentiated most of the patients correctly and BST might be used as an exclusion test. However, additional MBT and BST had no diagnostic advantage in FM. NHP still remain a group of patients, which cannot be identified using the recommended CH
4
cut-off values in FM or LM. Reported symptoms during breath tests are not a reliable method to diagnose FM/LM. Overall a combined test approach might help in diagnosing children with suspected carbohydrate malabsorption.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75987-6</identifier><identifier>PMID: 33149229</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/3187 ; 692/4020 ; 692/699/1702/295 ; Adolescent ; Blood ; Blood Glucose ; Breath Tests ; Carbohydrates ; Child ; Child, Preschool ; Children ; Female ; Fructose Intolerance - blood ; Fructose Intolerance - diagnosis ; Humanities and Social Sciences ; Humans ; Hydrogen - analysis ; Lactose ; Lactose Intolerance - blood ; Lactose Intolerance - diagnosis ; Malabsorption ; Male ; Methane ; Methane - analysis ; multidisciplinary ; Patients ; Pediatrics ; Reproducibility of Results ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Sugar</subject><ispartof>Scientific reports, 2020-11, Vol.10 (1), p.18972-18972, Article 18972</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-86aeafbfafe23e1f90227c2537aa4f6ee7efd42b4ce38b7d37ecf4b172ec4c743</citedby><cites>FETCH-LOGICAL-c474t-86aeafbfafe23e1f90227c2537aa4f6ee7efd42b4ce38b7d37ecf4b172ec4c743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643139/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643139/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33149229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, Christof</creatorcontrib><creatorcontrib>Wutzke, Klaus D.</creatorcontrib><creatorcontrib>Däbritz, Jan</creatorcontrib><title>Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Carbohydrate malabsorption and subsequent gastrointestinal symptoms are a common clinical problem in pediatrics. Hydrogen (H
2
) and methane (CH
4
) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well as the impact of non-hydrogen producers (NHP) is unclear. CH
4
breath tests (MBT), blood sugar tests (BST) and clinical symptoms were compared with H
2
breath tests (HBT) for FM/LM. 187/82 tests were performed in children (2 to 18 years) with unclear chronic/recurrent abdominal pain and suspected FM/LM. In FM and LM, we found a significant correlation between HBT and MBT/BST. In LM, MBT differentiated most of the patients correctly and BST might be used as an exclusion test. However, additional MBT and BST had no diagnostic advantage in FM. NHP still remain a group of patients, which cannot be identified using the recommended CH
4
cut-off values in FM or LM. Reported symptoms during breath tests are not a reliable method to diagnose FM/LM. Overall a combined test approach might help in diagnosing children with suspected carbohydrate malabsorption.</description><subject>692/308/3187</subject><subject>692/4020</subject><subject>692/699/1702/295</subject><subject>Adolescent</subject><subject>Blood</subject><subject>Blood Glucose</subject><subject>Breath Tests</subject><subject>Carbohydrates</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Female</subject><subject>Fructose Intolerance - blood</subject><subject>Fructose Intolerance - diagnosis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hydrogen - analysis</subject><subject>Lactose</subject><subject>Lactose Intolerance - blood</subject><subject>Lactose Intolerance - diagnosis</subject><subject>Malabsorption</subject><subject>Male</subject><subject>Methane</subject><subject>Methane - analysis</subject><subject>multidisciplinary</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sugar</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1vFSEUhomxsU3bP-DCkLhxM3X4mGHYmJjGjyZt3OgaD8zhzjRz4QqMpv9e6r3W6kI2nHCe88LLS8hz1l6wVgyvs2SdHpqWt42qhWr6J-SEt7JruOD86aP6mJznfNvW1XEtmX5GjoVgUnOuT8jXGywTBKQ2IZSJFswlUwgjtUuMI83rBtLhdA7UTfMyJgz0x1zhvOYduoIjdZBsnO7GBAXpFhawOaZdmWM4I0celoznh_2UfHn_7vPlx-b604ery7fXjZNKlmboAcFbDx65QOZ1y7lyvBMKQPoeUaEfJbfSoRisGoVC56VliqOTTklxSt7sdXer3eLoMJQEi9mleQvpzkSYzd-dME9mE78b1UvBhK4Crw4CKX5bq2GznbPDZam_E9dsuOyU7nXXDxV9-Q96G9cUqr1KKdaJgfWsUnxPuRRzTugfHsNac5-h2WdoaobmV4amr0MvHtt4GPmdWAXEHsi1FTaY_tz9H9mf8leqpw</recordid><startdate>20201104</startdate><enddate>20201104</enddate><creator>Schneider, Christof</creator><creator>Wutzke, Klaus D.</creator><creator>Däbritz, Jan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201104</creationdate><title>Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption</title><author>Schneider, Christof ; Wutzke, Klaus D. ; Däbritz, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-86aeafbfafe23e1f90227c2537aa4f6ee7efd42b4ce38b7d37ecf4b172ec4c743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/308/3187</topic><topic>692/4020</topic><topic>692/699/1702/295</topic><topic>Adolescent</topic><topic>Blood</topic><topic>Blood Glucose</topic><topic>Breath Tests</topic><topic>Carbohydrates</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Female</topic><topic>Fructose Intolerance - blood</topic><topic>Fructose Intolerance - diagnosis</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hydrogen - analysis</topic><topic>Lactose</topic><topic>Lactose Intolerance - blood</topic><topic>Lactose Intolerance - diagnosis</topic><topic>Malabsorption</topic><topic>Male</topic><topic>Methane</topic><topic>Methane - analysis</topic><topic>multidisciplinary</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sugar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Christof</creatorcontrib><creatorcontrib>Wutzke, Klaus D.</creatorcontrib><creatorcontrib>Däbritz, Jan</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Christof</au><au>Wutzke, Klaus D.</au><au>Däbritz, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-11-04</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>18972</spage><epage>18972</epage><pages>18972-18972</pages><artnum>18972</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Carbohydrate malabsorption and subsequent gastrointestinal symptoms are a common clinical problem in pediatrics. Hydrogen (H
2
) and methane (CH
4
) breath tests are a cheap and non-invasive procedure for diagnosing fructose and lactose malabsorption (FM/LM) but test accuracy and reliability as well as the impact of non-hydrogen producers (NHP) is unclear. CH
4
breath tests (MBT), blood sugar tests (BST) and clinical symptoms were compared with H
2
breath tests (HBT) for FM/LM. 187/82 tests were performed in children (2 to 18 years) with unclear chronic/recurrent abdominal pain and suspected FM/LM. In FM and LM, we found a significant correlation between HBT and MBT/BST. In LM, MBT differentiated most of the patients correctly and BST might be used as an exclusion test. However, additional MBT and BST had no diagnostic advantage in FM. NHP still remain a group of patients, which cannot be identified using the recommended CH
4
cut-off values in FM or LM. Reported symptoms during breath tests are not a reliable method to diagnose FM/LM. Overall a combined test approach might help in diagnosing children with suspected carbohydrate malabsorption.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33149229</pmid><doi>10.1038/s41598-020-75987-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/3187 692/4020 692/699/1702/295 Adolescent Blood Blood Glucose Breath Tests Carbohydrates Child Child, Preschool Children Female Fructose Intolerance - blood Fructose Intolerance - diagnosis Humanities and Social Sciences Humans Hydrogen - analysis Lactose Lactose Intolerance - blood Lactose Intolerance - diagnosis Malabsorption Male Methane Methane - analysis multidisciplinary Patients Pediatrics Reproducibility of Results Retrospective Studies Science Science (multidisciplinary) Sugar |
| title | Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption |
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