Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia
In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infec...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.19023, Article 19023 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 19023 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Kurniawan, Farid Tahapary, Dicky L. de Ruiter, Karin Yunir, Em Biermasz, Nienke R. Smit, Johannes W. A. Supali, Taniawati Sartono, Erliyani Yazdanbakhsh, Maria Soewondo, Pradana |
| description | In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI − 0.068 (− 0.103; − 0.033), P |
| doi_str_mv | 10.1038/s41598-020-75781-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7643058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471538541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-e61acfe6ee4069dbee729127f0f14241bdd24552354ad71e3602bf3262efd6f43</originalsourceid><addsrcrecordid>eNp9UU1vVSEQJUZjm9o_4MKQuKbCAPfDhYk2bX1JE13omvAuQ0tzL1TgNtFfX56v1rqRzUzmHM6cySHkteAngsvhXVFCjwPjwFmv-0Ew9YwcAleagQR4_qQ_IMel3PD2NIxKjC_JgZRCjcD1Ialn3uNUafLUxnqN8xJiDROtGW1dMDYk0oJ5XajPiHRzcc5Eo7pd9-krk--ppdO8loqZ5TZPS_iFjk0p1pzmGV2TCnamIdJNQyOWYF-RF97OBY8f6hH5fn727fQzu_xysTn9eMkm1avKsBN28tghKt6NbovYwyig99wLBUpsnQOlNUitrOsFyo7D1kvoAL3rvJJH5MNe93bdLuimdk62s7nNYbH5p0k2mH-RGK7NVbozfack10MTePsgkNOPFUs1N2nNsXk2oHqh5aCVaCzYs6acSsnoHzcIbnZhmX1YpoVlfodldt7ePPX2-OVPNI0g94TSoHiF-e_u_8jeA47PoDw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471538541</pqid></control><display><type>article</type><title>Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Kurniawan, Farid ; Tahapary, Dicky L. ; de Ruiter, Karin ; Yunir, Em ; Biermasz, Nienke R. ; Smit, Johannes W. A. ; Supali, Taniawati ; Sartono, Erliyani ; Yazdanbakhsh, Maria ; Soewondo, Pradana</creator><creatorcontrib>Kurniawan, Farid ; Tahapary, Dicky L. ; de Ruiter, Karin ; Yunir, Em ; Biermasz, Nienke R. ; Smit, Johannes W. A. ; Supali, Taniawati ; Sartono, Erliyani ; Yazdanbakhsh, Maria ; Soewondo, Pradana</creatorcontrib><description>In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI − 0.068 (− 0.103; − 0.033), P < 0.001 after adjustment for age, sex, body mass index, and fasting insulin level]. There was no difference in IGFBP-3 level between helminth infected versus non-infected subjects. In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; − 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population.
Clinical Trial Registration
:
https://www.isrctn.com/ISRCTN75636394
.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75781-4</identifier><identifier>PMID: 33149205</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163 ; 692/163/2743 ; 692/420 ; 692/420/254 ; Adult ; Albendazole ; Albendazole - therapeutic use ; Anthelmintic agents ; Anthelmintics - therapeutic use ; Antiparasitic agents ; Body mass index ; Case-Control Studies ; Child ; Child, Preschool ; Clinical trials ; Cluster Analysis ; Female ; Growth rate ; Helminthiasis - blood ; Helminthiasis - drug therapy ; Humanities and Social Sciences ; Humans ; Indonesia ; Infections ; Insulin ; Insulin-Like Growth Factor Binding Protein 3 - metabolism ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - metabolism ; Insulin-like growth factor-binding protein 3 ; Male ; multidisciplinary ; Nutritional status ; Placebos ; Population studies ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-11, Vol.10 (1), p.19023, Article 19023</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e61acfe6ee4069dbee729127f0f14241bdd24552354ad71e3602bf3262efd6f43</citedby><cites>FETCH-LOGICAL-c474t-e61acfe6ee4069dbee729127f0f14241bdd24552354ad71e3602bf3262efd6f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643058/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643058/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33149205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurniawan, Farid</creatorcontrib><creatorcontrib>Tahapary, Dicky L.</creatorcontrib><creatorcontrib>de Ruiter, Karin</creatorcontrib><creatorcontrib>Yunir, Em</creatorcontrib><creatorcontrib>Biermasz, Nienke R.</creatorcontrib><creatorcontrib>Smit, Johannes W. A.</creatorcontrib><creatorcontrib>Supali, Taniawati</creatorcontrib><creatorcontrib>Sartono, Erliyani</creatorcontrib><creatorcontrib>Yazdanbakhsh, Maria</creatorcontrib><creatorcontrib>Soewondo, Pradana</creatorcontrib><title>Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI − 0.068 (− 0.103; − 0.033), P < 0.001 after adjustment for age, sex, body mass index, and fasting insulin level]. There was no difference in IGFBP-3 level between helminth infected versus non-infected subjects. In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; − 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population.
Clinical Trial Registration
:
https://www.isrctn.com/ISRCTN75636394
.</description><subject>692/163</subject><subject>692/163/2743</subject><subject>692/420</subject><subject>692/420/254</subject><subject>Adult</subject><subject>Albendazole</subject><subject>Albendazole - therapeutic use</subject><subject>Anthelmintic agents</subject><subject>Anthelmintics - therapeutic use</subject><subject>Antiparasitic agents</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical trials</subject><subject>Cluster Analysis</subject><subject>Female</subject><subject>Growth rate</subject><subject>Helminthiasis - blood</subject><subject>Helminthiasis - drug therapy</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Indonesia</subject><subject>Infections</subject><subject>Insulin</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - metabolism</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-like growth factor-binding protein 3</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Nutritional status</subject><subject>Placebos</subject><subject>Population studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UU1vVSEQJUZjm9o_4MKQuKbCAPfDhYk2bX1JE13omvAuQ0tzL1TgNtFfX56v1rqRzUzmHM6cySHkteAngsvhXVFCjwPjwFmv-0Ew9YwcAleagQR4_qQ_IMel3PD2NIxKjC_JgZRCjcD1Ialn3uNUafLUxnqN8xJiDROtGW1dMDYk0oJ5XajPiHRzcc5Eo7pd9-krk--ppdO8loqZ5TZPS_iFjk0p1pzmGV2TCnamIdJNQyOWYF-RF97OBY8f6hH5fn727fQzu_xysTn9eMkm1avKsBN28tghKt6NbovYwyig99wLBUpsnQOlNUitrOsFyo7D1kvoAL3rvJJH5MNe93bdLuimdk62s7nNYbH5p0k2mH-RGK7NVbozfack10MTePsgkNOPFUs1N2nNsXk2oHqh5aCVaCzYs6acSsnoHzcIbnZhmX1YpoVlfodldt7ePPX2-OVPNI0g94TSoHiF-e_u_8jeA47PoDw</recordid><startdate>20201104</startdate><enddate>20201104</enddate><creator>Kurniawan, Farid</creator><creator>Tahapary, Dicky L.</creator><creator>de Ruiter, Karin</creator><creator>Yunir, Em</creator><creator>Biermasz, Nienke R.</creator><creator>Smit, Johannes W. A.</creator><creator>Supali, Taniawati</creator><creator>Sartono, Erliyani</creator><creator>Yazdanbakhsh, Maria</creator><creator>Soewondo, Pradana</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20201104</creationdate><title>Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia</title><author>Kurniawan, Farid ; Tahapary, Dicky L. ; de Ruiter, Karin ; Yunir, Em ; Biermasz, Nienke R. ; Smit, Johannes W. A. ; Supali, Taniawati ; Sartono, Erliyani ; Yazdanbakhsh, Maria ; Soewondo, Pradana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e61acfe6ee4069dbee729127f0f14241bdd24552354ad71e3602bf3262efd6f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/163</topic><topic>692/163/2743</topic><topic>692/420</topic><topic>692/420/254</topic><topic>Adult</topic><topic>Albendazole</topic><topic>Albendazole - therapeutic use</topic><topic>Anthelmintic agents</topic><topic>Anthelmintics - therapeutic use</topic><topic>Antiparasitic agents</topic><topic>Body mass index</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical trials</topic><topic>Cluster Analysis</topic><topic>Female</topic><topic>Growth rate</topic><topic>Helminthiasis - blood</topic><topic>Helminthiasis - drug therapy</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Indonesia</topic><topic>Infections</topic><topic>Insulin</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - metabolism</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-like growth factor-binding protein 3</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Nutritional status</topic><topic>Placebos</topic><topic>Population studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurniawan, Farid</creatorcontrib><creatorcontrib>Tahapary, Dicky L.</creatorcontrib><creatorcontrib>de Ruiter, Karin</creatorcontrib><creatorcontrib>Yunir, Em</creatorcontrib><creatorcontrib>Biermasz, Nienke R.</creatorcontrib><creatorcontrib>Smit, Johannes W. A.</creatorcontrib><creatorcontrib>Supali, Taniawati</creatorcontrib><creatorcontrib>Sartono, Erliyani</creatorcontrib><creatorcontrib>Yazdanbakhsh, Maria</creatorcontrib><creatorcontrib>Soewondo, Pradana</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurniawan, Farid</au><au>Tahapary, Dicky L.</au><au>de Ruiter, Karin</au><au>Yunir, Em</au><au>Biermasz, Nienke R.</au><au>Smit, Johannes W. A.</au><au>Supali, Taniawati</au><au>Sartono, Erliyani</au><au>Yazdanbakhsh, Maria</au><au>Soewondo, Pradana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-11-04</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>19023</spage><pages>19023-</pages><artnum>19023</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI − 0.068 (− 0.103; − 0.033), P < 0.001 after adjustment for age, sex, body mass index, and fasting insulin level]. There was no difference in IGFBP-3 level between helminth infected versus non-infected subjects. In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; − 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population.
Clinical Trial Registration
:
https://www.isrctn.com/ISRCTN75636394
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33149205</pmid><doi>10.1038/s41598-020-75781-4</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-11, Vol.10 (1), p.19023, Article 19023 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7643058 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 692/163 692/163/2743 692/420 692/420/254 Adult Albendazole Albendazole - therapeutic use Anthelmintic agents Anthelmintics - therapeutic use Antiparasitic agents Body mass index Case-Control Studies Child Child, Preschool Clinical trials Cluster Analysis Female Growth rate Helminthiasis - blood Helminthiasis - drug therapy Humanities and Social Sciences Humans Indonesia Infections Insulin Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factor-binding protein 3 Male multidisciplinary Nutritional status Placebos Population studies Science Science (multidisciplinary) |
| title | Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T03%3A47%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20anthelmintic%20treatment%20on%20serum%20free%20IGF-1%20and%20IGFBP-3:%20a%20cluster-randomized-controlled%20trial%20in%20Indonesia&rft.jtitle=Scientific%20reports&rft.au=Kurniawan,%20Farid&rft.date=2020-11-04&rft.volume=10&rft.issue=1&rft.spage=19023&rft.pages=19023-&rft.artnum=19023&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-75781-4&rft_dat=%3Cproquest_pubme%3E2471538541%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471538541&rft_id=info:pmid/33149205&rfr_iscdi=true |