Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer

The recent approval of anti-programmed death-ligand 1 immunotherapy in combination with nab-paclitaxel for metastatic triple-negative breast cancer (TNBC) highlights the need to understand the role of chemotherapy in modulating the tumor immune microenvironment (TIME). We examined immune-related gen...

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Veröffentlicht in:	Clinical cancer research 2020-11, Vol.26 (21), p.5668-5681
Hauptverfasser:	Axelrod, Margaret L, Nixon, Mellissa J, Gonzalez-Ericsson, Paula I, Bergman, Riley E, Pilkinton, Mark A, McDonnell, Wyatt J, Sanchez, Violeta, Opalenik, Susan R, Loi, Sherene, Zhou, Jing, Mackay, Sean, Rexer, Brent N, Abramson, Vandana G, Jansen, Valerie M, Mallal, Simon, Donaldson, Joshua, Tolaney, Sara M, Krop, Ian E, Garrido-Castro, Ana C, Marotti, Jonathan D, Shee, Kevin, Miller, Todd W, Sanders, Melinda E, Mayer, Ingrid A, Salgado, Roberto, Balko, Justin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Albumins - administration & dosage Albumins - adverse effects Antineoplastic Combined Chemotherapy Protocols B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - genetics CD8-Positive T-Lymphocytes - drug effects Female Gene Expression Regulation, Neoplastic - drug effects Humans Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Middle Aged Neoadjuvant Therapy - adverse effects Neoplasm Proteins - genetics Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - pathology Paclitaxel - administration & dosage Paclitaxel - adverse effects Prognosis Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - genetics Progression-Free Survival Treatment Outcome Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - immunology Triple Negative Breast Neoplasms - pathology Tumor Microenvironment - drug effects
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