Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy

Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found that activating a β-catenin-independent branch of WNT signaling...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer discovery 2020-11, Vol.10 (11), p.1690-1705
Hauptverfasser:	Hinze, Laura, Labrosse, Roxane, Degar, James, Han, Teng, Schatoff, Emma M, Schreek, Sabine, Karim, Salmaan, McGuckin, Connor, Sacher, Joshua R, Wagner, Florence, Stanulla, Martin, Yuan, Chen, Sicinska, Ewa, Giannakis, Marios, Ng, Kimmie, Dow, Lukas E, Gutierrez, Alejandro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!