Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis
Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRI...
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| description | Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and the MOOSE reporting guideline. Based on a preregistered protocol (PROSPERO—CRD42019138430), a comprehensive search of eight databases was performed from inception to April 2020. Studies with original data collected from patients with thyroid dysfunction were included. Subgroup analysis was performed based on the different types of clinical manifestations and patient characteristics. The quality of each study and the presence of publication bias were assessed by the Newcastle-Ottawa score (NOS) and funnel plot with Egger’s test, respectively. A total of 11 studies with 1210 participants were included. Ten studies were identified as high-quality studies. Pooled analysis indicated decreased irisin levels in patients with hypothyroidism (MD -10.37, 95% CI -17.81 to -2.93). Subgroup analysis revealed an even lower level of irisin in patients with clinical-type hypothyroidism (MD -17.03, 95% CI -30.58 to -3.49) and hypothyroidism caused by autoimmune disease (MD -19.38, 95% CI -36.50 to -2.26). No differences were found after achieving euthyroid status from levothyroxine treatment in patients with hypothyroidism compared with controls. No differences were found between patients with hyperthyroidism and controls. Correlation analyses revealed a possible negative correlation between irisin and TSH and positive correlations between irisin and both fT3 and fT4. Irisin was correlated with TSH receptor antibodies. |
| doi_str_mv | 10.1155/2020/2182735 |
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Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and the MOOSE reporting guideline. Based on a preregistered protocol (PROSPERO—CRD42019138430), a comprehensive search of eight databases was performed from inception to April 2020. Studies with original data collected from patients with thyroid dysfunction were included. Subgroup analysis was performed based on the different types of clinical manifestations and patient characteristics. The quality of each study and the presence of publication bias were assessed by the Newcastle-Ottawa score (NOS) and funnel plot with Egger’s test, respectively. A total of 11 studies with 1210 participants were included. Ten studies were identified as high-quality studies. Pooled analysis indicated decreased irisin levels in patients with hypothyroidism (MD -10.37, 95% CI -17.81 to -2.93). Subgroup analysis revealed an even lower level of irisin in patients with clinical-type hypothyroidism (MD -17.03, 95% CI -30.58 to -3.49) and hypothyroidism caused by autoimmune disease (MD -19.38, 95% CI -36.50 to -2.26). No differences were found after achieving euthyroid status from levothyroxine treatment in patients with hypothyroidism compared with controls. No differences were found between patients with hyperthyroidism and controls. Correlation analyses revealed a possible negative correlation between irisin and TSH and positive correlations between irisin and both fT3 and fT4. Irisin was correlated with TSH receptor antibodies.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/2182735</identifier><identifier>PMID: 33195690</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adipocytes ; Antibodies ; Antibodies - blood ; Autoimmune diseases ; Autoimmune Diseases - blood ; Autoimmune Diseases - physiopathology ; Bias ; Cardiovascular system ; Correlation analysis ; Diagnosis ; Disease ; Female ; Fibronectins - blood ; Health aspects ; Hormones ; Humans ; Hyperthyroidism ; Hyperthyroidism - blood ; Hyperthyroidism - physiopathology ; Hypothyroidism ; Hypothyroidism - blood ; Hypothyroidism - drug therapy ; Hypothyroidism - physiopathology ; Male ; Measurement ; Meta-analysis ; Metabolism ; Patients ; Protein hormones ; Proteins ; Publication Bias ; Review ; Risk factors ; Subgroups ; Systematic review ; Thermogenesis ; Thyroid ; Thyroid diseases ; Thyroid gland ; Thyroid Gland - drug effects ; Thyroid Gland - physiopathology ; Thyroid hormones ; Thyroid-stimulating hormone ; Thyroxine ; Thyroxine - pharmacology ; Thyroxine - therapeutic use</subject><ispartof>BioMed research international, 2020, Vol.2020 (2020), p.1-11</ispartof><rights>Copyright © 2020 Dan Shan et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Dan Shan et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Dan Shan et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-be33eade64d6c0c758d636531c46de3ec2c78ec526a7150c4a60003783047ad23</citedby><cites>FETCH-LOGICAL-c499t-be33eade64d6c0c758d636531c46de3ec2c78ec526a7150c4a60003783047ad23</cites><orcidid>0000-0002-5555-4508 ; 0000-0002-0722-5267 ; 0000-0002-6900-0696 ; 0000-0002-9108-1453 ; 0000-0001-6865-2388 ; 0000-0002-2912-5697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641689/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641689/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33195690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bertero, Luca</contributor><contributor>Luca Bertero</contributor><creatorcontrib>Dong, Ruihong</creatorcontrib><creatorcontrib>Cai, Yitong</creatorcontrib><creatorcontrib>Liu, Xijiao</creatorcontrib><creatorcontrib>Zou, Li</creatorcontrib><creatorcontrib>Shan, Dan</creatorcontrib><creatorcontrib>Hu, Yayi</creatorcontrib><title>Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and the MOOSE reporting guideline. Based on a preregistered protocol (PROSPERO—CRD42019138430), a comprehensive search of eight databases was performed from inception to April 2020. Studies with original data collected from patients with thyroid dysfunction were included. Subgroup analysis was performed based on the different types of clinical manifestations and patient characteristics. The quality of each study and the presence of publication bias were assessed by the Newcastle-Ottawa score (NOS) and funnel plot with Egger’s test, respectively. A total of 11 studies with 1210 participants were included. Ten studies were identified as high-quality studies. Pooled analysis indicated decreased irisin levels in patients with hypothyroidism (MD -10.37, 95% CI -17.81 to -2.93). Subgroup analysis revealed an even lower level of irisin in patients with clinical-type hypothyroidism (MD -17.03, 95% CI -30.58 to -3.49) and hypothyroidism caused by autoimmune disease (MD -19.38, 95% CI -36.50 to -2.26). No differences were found after achieving euthyroid status from levothyroxine treatment in patients with hypothyroidism compared with controls. No differences were found between patients with hyperthyroidism and controls. Correlation analyses revealed a possible negative correlation between irisin and TSH and positive correlations between irisin and both fT3 and fT4. Irisin was correlated with TSH receptor antibodies.</description><subject>Adipocytes</subject><subject>Antibodies</subject><subject>Antibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - physiopathology</subject><subject>Bias</subject><subject>Cardiovascular system</subject><subject>Correlation analysis</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Female</subject><subject>Fibronectins - blood</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Hyperthyroidism - blood</subject><subject>Hyperthyroidism - physiopathology</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - drug therapy</subject><subject>Hypothyroidism - physiopathology</subject><subject>Male</subject><subject>Measurement</subject><subject>Meta-analysis</subject><subject>Metabolism</subject><subject>Patients</subject><subject>Protein hormones</subject><subject>Proteins</subject><subject>Publication Bias</subject><subject>Review</subject><subject>Risk factors</subject><subject>Subgroups</subject><subject>Systematic review</subject><subject>Thermogenesis</subject><subject>Thyroid</subject><subject>Thyroid diseases</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyroid hormones</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>Thyroxine - pharmacology</subject><subject>Thyroxine - therapeutic use</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1vEzEQxVcIRKvSG2e0EhckWOrvtTkgRaFApSAkKOJoufYkcbWxW3s31f73dZqQtpzqy1ia37yZp1dVrzH6iDHnJwQRdEKwJC3lz6pDQjFrBGb4-f5P6UF1nPMlKk9igZR4WR1QihUXCh1Wf6c-2aEzvQ-L-iz57EM9gzV0tQmuPl-OKXpXfxnzfAi29zF8qif17zH3sCoztv4Faw83d_AP6E0zCaYbs8-vqhdz02U43tWj6s_X0_Pp92b289vZdDJrLFOqby6AUjAOBHPCItty6QQVnGLLhAMKlthWguVEmBZzZJkRxQdtJUWsNY7Qo-rzVvdquFiBsxD6ZDp9lfzKpFFH4_XjTvBLvYhr3QqGhVRF4N1OIMXrAXKvVz5b6DoTIA5ZEyYwQkwqXNC3_6GXcUjF8IbikpXrubqnFqYD7cM8lr12I6onQrUIS0FRoT5sKZtizgnm-5Mx0pto9SZavYu24G8e2tzD_4IswPstsPTBmRv_RLmSYtlt7mlMCUOE3gLAVrNG</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Dong, Ruihong</creator><creator>Cai, Yitong</creator><creator>Liu, Xijiao</creator><creator>Zou, Li</creator><creator>Shan, Dan</creator><creator>Hu, Yayi</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5555-4508</orcidid><orcidid>https://orcid.org/0000-0002-0722-5267</orcidid><orcidid>https://orcid.org/0000-0002-6900-0696</orcidid><orcidid>https://orcid.org/0000-0002-9108-1453</orcidid><orcidid>https://orcid.org/0000-0001-6865-2388</orcidid><orcidid>https://orcid.org/0000-0002-2912-5697</orcidid></search><sort><creationdate>2020</creationdate><title>Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis</title><author>Dong, Ruihong ; Cai, Yitong ; Liu, Xijiao ; Zou, Li ; Shan, Dan ; Hu, Yayi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-be33eade64d6c0c758d636531c46de3ec2c78ec526a7150c4a60003783047ad23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipocytes</topic><topic>Antibodies</topic><topic>Antibodies - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Ruihong</au><au>Cai, Yitong</au><au>Liu, Xijiao</au><au>Zou, Li</au><au>Shan, Dan</au><au>Hu, Yayi</au><au>Bertero, Luca</au><au>Luca Bertero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Both thyroid hormones and irisin have profound influences on the metabolism of the human body. Based on their similarities, several studies have been conducted to explore changes in irisin levels in patients with hypothyroidism and hyperthyroidism. This study was conducted in accordance with the PRISMA statement and the MOOSE reporting guideline. Based on a preregistered protocol (PROSPERO—CRD42019138430), a comprehensive search of eight databases was performed from inception to April 2020. Studies with original data collected from patients with thyroid dysfunction were included. Subgroup analysis was performed based on the different types of clinical manifestations and patient characteristics. The quality of each study and the presence of publication bias were assessed by the Newcastle-Ottawa score (NOS) and funnel plot with Egger’s test, respectively. A total of 11 studies with 1210 participants were included. Ten studies were identified as high-quality studies. Pooled analysis indicated decreased irisin levels in patients with hypothyroidism (MD -10.37, 95% CI -17.81 to -2.93). Subgroup analysis revealed an even lower level of irisin in patients with clinical-type hypothyroidism (MD -17.03, 95% CI -30.58 to -3.49) and hypothyroidism caused by autoimmune disease (MD -19.38, 95% CI -36.50 to -2.26). No differences were found after achieving euthyroid status from levothyroxine treatment in patients with hypothyroidism compared with controls. No differences were found between patients with hyperthyroidism and controls. Correlation analyses revealed a possible negative correlation between irisin and TSH and positive correlations between irisin and both fT3 and fT4. Irisin was correlated with TSH receptor antibodies.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>33195690</pmid><doi>10.1155/2020/2182735</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5555-4508</orcidid><orcidid>https://orcid.org/0000-0002-0722-5267</orcidid><orcidid>https://orcid.org/0000-0002-6900-0696</orcidid><orcidid>https://orcid.org/0000-0002-9108-1453</orcidid><orcidid>https://orcid.org/0000-0001-6865-2388</orcidid><orcidid>https://orcid.org/0000-0002-2912-5697</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Antibodies Antibodies - blood Autoimmune diseases Autoimmune Diseases - blood Autoimmune Diseases - physiopathology Bias Cardiovascular system Correlation analysis Diagnosis Disease Female Fibronectins - blood Health aspects Hormones Humans Hyperthyroidism Hyperthyroidism - blood Hyperthyroidism - physiopathology Hypothyroidism Hypothyroidism - blood Hypothyroidism - drug therapy Hypothyroidism - physiopathology Male Measurement Meta-analysis Metabolism Patients Protein hormones Proteins Publication Bias Review Risk factors Subgroups Systematic review Thermogenesis Thyroid Thyroid diseases Thyroid gland Thyroid Gland - drug effects Thyroid Gland - physiopathology Thyroid hormones Thyroid-stimulating hormone Thyroxine Thyroxine - pharmacology Thyroxine - therapeutic use |
| title | Circulating Irisin Level and Thyroid Dysfunction: A Systematic Review and Meta-Analysis |
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