The methyltransferase TrmA facilitates tRNA folding through interaction with its RNA-binding domain

Abstract tRNAs are the most highly modified RNAs in all cells, and formation of 5-methyluridine (m5U) at position 54 in the T arm is a common RNA modification found in all tRNAs. The m5U modification is generated by the methyltransferase TrmA. Here, we test and prove the hypothesis that Escherichia...

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Veröffentlicht in:Nucleic acids research 2020-08, Vol.48 (14), p.7981-7990
Hauptverfasser: Keffer-Wilkes, Laura Carole, Soon, Emily F, Kothe, Ute
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Sprache:eng
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