Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations
To determine if metabolic characteristics differed in women with and without polycystic ovary syndrome (PCOS) between a Caucasian and Middle East population. Comparative cross-sectional analysis. Demographic and metabolic data from Middle Eastern women from Qatar Biobank (97 with PCOS, 622 controls)...
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| Veröffentlicht in: | Scientific reports 2020-11, Vol.10 (1), p.18895-18895, Article 18895 |
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| creator | Butler, Alexandra E. Abouseif, Ahmed Dargham, Soha R. Sathyapalan, Thozhukat Atkin, Stephen L. |
| description | To determine if metabolic characteristics differed in women with and without polycystic ovary syndrome (PCOS) between a Caucasian and Middle East population. Comparative cross-sectional analysis. Demographic and metabolic data from Middle Eastern women from Qatar Biobank (97 with PCOS, 622 controls) were compared to a Caucasian PCOS biobank in Hull UK (108 with PCOS, 69 controls). In both populations, PCOS women showed a worse cardiovascular risk profile of increased systolic and diastolic blood pressure, increased C-reactive protein (CRP), reduced HDL, insulin resistance as well as increased androgens compared to their respective controls without PCOS. UK women without PCOS had higher systolic and diastolic blood pressures, and increased testosterone results (p |
| doi_str_mv | 10.1038/s41598-020-75109-2 |
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Comparative cross-sectional analysis. Demographic and metabolic data from Middle Eastern women from Qatar Biobank (97 with PCOS, 622 controls) were compared to a Caucasian PCOS biobank in Hull UK (108 with PCOS, 69 controls). In both populations, PCOS women showed a worse cardiovascular risk profile of increased systolic and diastolic blood pressure, increased C-reactive protein (CRP), reduced HDL, insulin resistance as well as increased androgens compared to their respective controls without PCOS. UK women without PCOS had higher systolic and diastolic blood pressures, and increased testosterone results (p < 0.01) compared to Middle Eastern women without PCOS who had higher inflammatory markers (WBC and CRP), HDL and insulin resistance (p < 0.001). UK PCOS women had a higher body mass index, systolic and diastolic blood pressures, triglycerides (p < 0.01), whilst Middle Eastern PCOS women showed increased testosterone, free androgen index, HDL and CRP (P < 0.01). There was no difference in insulin or insulin resistance between the two PCOS cohorts. This study highlights ethnic population differences because, whilst cardiovascular risk indices were increased for both PCOS cohorts, this may be for different reasons: BMI, waist and hip measurements, systolic and diastolic blood pressure, and triglycerides were higher in the UK cohort whilst testosterone, HDL and CRP were higher in the Middle East population. Insulin resistance did not differ between the two PCOS populations despite differences in BMI.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75109-2</identifier><identifier>PMID: 33144665</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163 ; 692/163/2743 ; Adult ; Androgens ; Biobanks ; Biomarkers - metabolism ; Blood pressure ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - metabolism ; Case-Control Studies ; Cholesterol, HDL - metabolism ; Cross-Sectional Studies ; Female ; Health risks ; High density lipoprotein ; Humanities and Social Sciences ; Humans ; Inflammation ; Insulin ; Insulin Resistance ; Metabolism ; Middle East - ethnology ; Minority & ethnic groups ; multidisciplinary ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - ethnology ; Polycystic Ovary Syndrome - metabolism ; Population studies ; Science ; Science (multidisciplinary) ; Testosterone ; Triglycerides ; United Kingdom - ethnology ; White People - ethnology ; White People - statistics & numerical data ; Young Adult</subject><ispartof>Scientific reports, 2020-11, Vol.10 (1), p.18895-18895, Article 18895</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Comparative cross-sectional analysis. Demographic and metabolic data from Middle Eastern women from Qatar Biobank (97 with PCOS, 622 controls) were compared to a Caucasian PCOS biobank in Hull UK (108 with PCOS, 69 controls). In both populations, PCOS women showed a worse cardiovascular risk profile of increased systolic and diastolic blood pressure, increased C-reactive protein (CRP), reduced HDL, insulin resistance as well as increased androgens compared to their respective controls without PCOS. UK women without PCOS had higher systolic and diastolic blood pressures, and increased testosterone results (p < 0.01) compared to Middle Eastern women without PCOS who had higher inflammatory markers (WBC and CRP), HDL and insulin resistance (p < 0.001). UK PCOS women had a higher body mass index, systolic and diastolic blood pressures, triglycerides (p < 0.01), whilst Middle Eastern PCOS women showed increased testosterone, free androgen index, HDL and CRP (P < 0.01). There was no difference in insulin or insulin resistance between the two PCOS cohorts. This study highlights ethnic population differences because, whilst cardiovascular risk indices were increased for both PCOS cohorts, this may be for different reasons: BMI, waist and hip measurements, systolic and diastolic blood pressure, and triglycerides were higher in the UK cohort whilst testosterone, HDL and CRP were higher in the Middle East population. Insulin resistance did not differ between the two PCOS populations despite differences in BMI.</description><subject>692/163</subject><subject>692/163/2743</subject><subject>Adult</subject><subject>Androgens</subject><subject>Biobanks</subject><subject>Biomarkers - metabolism</subject><subject>Blood pressure</subject><subject>Body Mass Index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Case-Control Studies</subject><subject>Cholesterol, HDL - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Health risks</subject><subject>High density lipoprotein</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Metabolism</subject><subject>Middle East - ethnology</subject><subject>Minority & ethnic groups</subject><subject>multidisciplinary</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - ethnology</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Population studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Testosterone</subject><subject>Triglycerides</subject><subject>United Kingdom - ethnology</subject><subject>White People - ethnology</subject><subject>White People - statistics & numerical data</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1PFTEUhhujEXLhD7gwTdy4GWlP25k7GxNzg2CAuJF10-kHlnTasZ2B3H9vLxcRXdDNac553vORF6F3lHyihK1PCqeiXzcESNMJSvoGXqFDIFw0wABeP_sfoONSbkl9AnpO-7fogDHKeduKQzRf2VkNKXiNdRonlX1JESeHpxS2elvmWkh3Na0iLttochotVtFUOs45BXxfExH7iK-8McHiU1Vmm-MDc32BN2rRquzUU5qWoGafYjlCb5wKxR4_xhW6_nr6Y3PeXH4_-7b5ctloAd3cODcMrhV1T6BW0KHXTLC1JVZxxgZluHBUWWvAsd5pMGptXNXwQbftwBxjK_R533dahtEabevKKsgp-1HlrUzKy38r0f-UN-lOdi2nUIet0MfHBjn9WmyZ5eiLtiGoaNNSJHDRtT3poKvoh__Q27TkWM-rVEcFAyp2FOwpnVMp2bqnZSiRO1_l3ldZfZUPvkqoovfPz3iS_HGxAmwPlFqKNzb_nf1C298Ad7GY</recordid><startdate>20201103</startdate><enddate>20201103</enddate><creator>Butler, Alexandra E.</creator><creator>Abouseif, Ahmed</creator><creator>Dargham, Soha R.</creator><creator>Sathyapalan, Thozhukat</creator><creator>Atkin, Stephen L.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201103</creationdate><title>Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations</title><author>Butler, Alexandra E. ; Abouseif, Ahmed ; Dargham, Soha R. ; Sathyapalan, Thozhukat ; Atkin, Stephen L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-ffbbf6566521e51b9c3538e0ea433bad45f1aeed2f39fc2da8dfffb4bc66b3f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/163</topic><topic>692/163/2743</topic><topic>Adult</topic><topic>Androgens</topic><topic>Biobanks</topic><topic>Biomarkers - metabolism</topic><topic>Blood pressure</topic><topic>Body Mass Index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Case-Control Studies</topic><topic>Cholesterol, HDL - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Health risks</topic><topic>High density lipoprotein</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Metabolism</topic><topic>Middle East - ethnology</topic><topic>Minority & ethnic groups</topic><topic>multidisciplinary</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - ethnology</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Population studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Testosterone</topic><topic>Triglycerides</topic><topic>United Kingdom - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butler, Alexandra E.</au><au>Abouseif, Ahmed</au><au>Dargham, Soha R.</au><au>Sathyapalan, Thozhukat</au><au>Atkin, Stephen L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-11-03</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>18895</spage><epage>18895</epage><pages>18895-18895</pages><artnum>18895</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>To determine if metabolic characteristics differed in women with and without polycystic ovary syndrome (PCOS) between a Caucasian and Middle East population. Comparative cross-sectional analysis. Demographic and metabolic data from Middle Eastern women from Qatar Biobank (97 with PCOS, 622 controls) were compared to a Caucasian PCOS biobank in Hull UK (108 with PCOS, 69 controls). In both populations, PCOS women showed a worse cardiovascular risk profile of increased systolic and diastolic blood pressure, increased C-reactive protein (CRP), reduced HDL, insulin resistance as well as increased androgens compared to their respective controls without PCOS. UK women without PCOS had higher systolic and diastolic blood pressures, and increased testosterone results (p < 0.01) compared to Middle Eastern women without PCOS who had higher inflammatory markers (WBC and CRP), HDL and insulin resistance (p < 0.001). UK PCOS women had a higher body mass index, systolic and diastolic blood pressures, triglycerides (p < 0.01), whilst Middle Eastern PCOS women showed increased testosterone, free androgen index, HDL and CRP (P < 0.01). There was no difference in insulin or insulin resistance between the two PCOS cohorts. This study highlights ethnic population differences because, whilst cardiovascular risk indices were increased for both PCOS cohorts, this may be for different reasons: BMI, waist and hip measurements, systolic and diastolic blood pressure, and triglycerides were higher in the UK cohort whilst testosterone, HDL and CRP were higher in the Middle East population. Insulin resistance did not differ between the two PCOS populations despite differences in BMI.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33144665</pmid><doi>10.1038/s41598-020-75109-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/163 692/163/2743 Adult Androgens Biobanks Biomarkers - metabolism Blood pressure Body Mass Index C-reactive protein C-Reactive Protein - metabolism Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Case-Control Studies Cholesterol, HDL - metabolism Cross-Sectional Studies Female Health risks High density lipoprotein Humanities and Social Sciences Humans Inflammation Insulin Insulin Resistance Metabolism Middle East - ethnology Minority & ethnic groups multidisciplinary Polycystic ovary syndrome Polycystic Ovary Syndrome - ethnology Polycystic Ovary Syndrome - metabolism Population studies Science Science (multidisciplinary) Testosterone Triglycerides United Kingdom - ethnology White People - ethnology White People - statistics & numerical data Young Adult |
| title | Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations |
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