Phenotype prediction and characterization of 25 pharmacogenes in Thais from whole genome sequencing for clinical implementation

Publicly available pharmacogenomics (PGx) databases enable translation of genotype data into clinically actionable information. As variation within pharmacogenes is population-specific, this study investigated the spectrum of 25 clinically relevant pharmacogenes in the Thai population (n = 291) from...

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Veröffentlicht in:	Scientific reports 2020-11, Vol.10 (1), p.18969, Article 18969
Hauptverfasser:	Mauleekoonphairoj, John, Chamnanphon, Monpat, Khongphatthanayothin, Apichai, Sutjaporn, Boosamas, Wandee, Pharawee, Poovorawan, Yong, Nademanee, Koonlawee, Pongpanich, Monnat, Chariyavilaskul, Pajaree
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/212 631/208/212/1728 631/208/728 Alleles Arylamine N-Acetyltransferase - genetics Bioinformatics Clinical trials Computational Biology CYP2D6 protein Cytochrome P-450 CYP2C19 - genetics Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP3A - genetics Cytochrome P450 Drug development Gene frequency Genomes Genomics - methods Genotype Genotypes Glucuronosyltransferase - genetics Haplotypes - genetics Humanities and Social Sciences Humans Liver-Specific Organic Anion Transporter 1 - genetics multidisciplinary Mutation - genetics Pharmacogenomics Phenotype Phenotypes Population Population studies Science Science (multidisciplinary) Side effects Thailand Variation Whole genome sequencing Whole Genome Sequencing - methods
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