Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants

Background/Objectives To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants. Subjects/Methods Infants ( n  = 238) and mothers ( n  = 193) randomly selected from participants in the neonatal vitamin A supplementation randomized control...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of clinical nutrition 2020-01, Vol.74 (1), p.97-105
Hauptverfasser: Kamenju, Pili, Hertzmark, Ellen, Kabagambe, Edmond K., Smith, Emily R., Muhihi, Alfa, Noor, Ramadhani A., Mshamu, Salum, Briegleb, Christina, Sudfeld, Christopher, Masanja, Honorati, Fawzi, Wafaie W.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 105
container_issue 1
container_start_page 97
container_title European journal of clinical nutrition
container_volume 74
creator Kamenju, Pili
Hertzmark, Ellen
Kabagambe, Edmond K.
Smith, Emily R.
Muhihi, Alfa
Noor, Ramadhani A.
Mshamu, Salum
Briegleb, Christina
Sudfeld, Christopher
Masanja, Honorati
Fawzi, Wafaie W.
description Background/Objectives To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants. Subjects/Methods Infants ( n  = 238) and mothers ( n  = 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum. Results All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08; P  
doi_str_mv 10.1038/s41430-019-0428-7
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7617056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A621865963</galeid><sourcerecordid>A621865963</sourcerecordid><originalsourceid>FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</originalsourceid><addsrcrecordid>eNp1kk1vEzEQhi0EoiHwA7iglZBQL1v8tfbuBamqWkCqxCV3a-odJ642dlh7i8Kvx2lK26AgH0b2PPN6ZvQS8p7RM0ZF-zlJJgWtKetqKnlb6xdkxqRWdaMkfUlmtGtkLSjVJ-RNSreUlqTmr8mJYJRL2rEZgSuwOY6pgpSi9ZCxr375vKo2A6Q1VKEWFYS-RFVt4rCdQoI8jfecg5y3FVjfVwPe4ZAqH6oFhN8QPIRycRByekteORgSvnuIc7K4ulxcfKuvf3z9fnF-XdtGiVwrLdoy1A1FqRope4m6B9GJxrUOQDpsVQ-tRd6A66hssXBOO2adptaBmJMve9nNdLPG3mLIIwxmM_o1jFsTwZvDTPArs4x3RiumaWlhTk4fBMb4c8KUzdoni8MAAeOUDOdM8VZISgv68R_0Nk5jKNMZLiTvNGVKPFFLGNCUbcTyr92JmnPFWaua7p6qj1BLDFiajAGdL88H_NkRvpwe194eLfj0rGCFMORVisOUfQzpEGR70I4xpRHd4_IYNTu_mb3fTPGb2fnN6FLz4fnWHyv-GqwAfA-kkgpLHJ9W9X_VP5KQ3rY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2342970163</pqid></control><display><type>article</type><title>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kamenju, Pili ; Hertzmark, Ellen ; Kabagambe, Edmond K. ; Smith, Emily R. ; Muhihi, Alfa ; Noor, Ramadhani A. ; Mshamu, Salum ; Briegleb, Christina ; Sudfeld, Christopher ; Masanja, Honorati ; Fawzi, Wafaie W.</creator><creatorcontrib>Kamenju, Pili ; Hertzmark, Ellen ; Kabagambe, Edmond K. ; Smith, Emily R. ; Muhihi, Alfa ; Noor, Ramadhani A. ; Mshamu, Salum ; Briegleb, Christina ; Sudfeld, Christopher ; Masanja, Honorati ; Fawzi, Wafaie W.</creatorcontrib><description>Background/Objectives To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants. Subjects/Methods Infants ( n  = 238) and mothers ( n  = 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum. Results All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08; P  &lt; 0.01). Infant plasma docosahexaenoic acid (DHA) levels were positively associated with maternal DHA levels (0.77 ± 0.09; P  &lt; 0.01) but were lower for twin births (−0.55 ± 0.27; P  = 0.03). Greater birth weight in kilograms (1.00 ± 0.43; P  = 0.02) and higher maternal n-6 PUFA levels (0.20 ± 0.07; P  &lt; 0.01) were positively associated with higher infant n-6 PUFA levels, whereas maternal mono-unsaturated fatty acid (MUFA) levels (−0.26 ± 0.08; P  &lt; 0.01), maternal mid upper arm circumference (MUAC) (−0.22 ± 0.11; P  = 0.04), and male sex (−0.99 ± 0.45; P  = 0.03) were associated with lower infant plasma n-6 PUFA levels. Infant plasma arachidonic acid (AA) levels were positively associated with maternal plasma AA levels (0.38 ± 0.09; P  &lt; 0.01), but inversely associated with twin births (−1.37 ± 0.67; P  = 0.04). Conclusions Greater birth weight and higher maternal plasma PUFA levels at 3 months postpartum were significantly associated with higher infant plasma PUFA levels at 3 months age. Twin births, male sex, and higher maternal MUFA levels were associated with lower infant plasma PUFA levels. Nutrition counseling for optimal intake of PUFA-rich foods, to lactating mothers in resource-limited settings may be beneficial for improved infant health.</description><identifier>ISSN: 0954-3007</identifier><identifier>ISSN: 1476-5640</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-019-0428-7</identifier><identifier>PMID: 31024091</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/700/1720 ; 692/700/2814 ; 692/700/478/174 ; Arachidonic acid ; Arm circumference ; Babies ; Baby foods ; Birth weight ; Births ; Clinical Nutrition ; Cross-Sectional Studies ; Dietary supplements ; Docosahexaenoic acid ; Docosahexaenoic Acids ; Epidemiology ; Fatty acids ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated ; Female ; Fish oils ; Food intake ; Health aspects ; Humans ; Infant ; Infant, Newborn ; Infants ; Infants (Newborn) ; Internal Medicine ; Lactation ; Male ; Medical research ; Medicine ; Medicine &amp; Public Health ; Medicine, Experimental ; Metabolic Diseases ; Neonates ; Nutrition ; Plasma ; Polyunsaturated fatty acids ; Postpartum ; Public Health ; Reorganization and restructuring ; Sex ; Standard error ; Unsaturated fatty acids ; Vitamin A ; Weight</subject><ispartof>European journal of clinical nutrition, 2020-01, Vol.74 (1), p.97-105</ispartof><rights>Springer Nature Limited 2019</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>Springer Nature Limited 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</citedby><cites>FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</cites><orcidid>0000-0003-2604-4354 ; 0000-0002-8993-3186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31024091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamenju, Pili</creatorcontrib><creatorcontrib>Hertzmark, Ellen</creatorcontrib><creatorcontrib>Kabagambe, Edmond K.</creatorcontrib><creatorcontrib>Smith, Emily R.</creatorcontrib><creatorcontrib>Muhihi, Alfa</creatorcontrib><creatorcontrib>Noor, Ramadhani A.</creatorcontrib><creatorcontrib>Mshamu, Salum</creatorcontrib><creatorcontrib>Briegleb, Christina</creatorcontrib><creatorcontrib>Sudfeld, Christopher</creatorcontrib><creatorcontrib>Masanja, Honorati</creatorcontrib><creatorcontrib>Fawzi, Wafaie W.</creatorcontrib><title>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants. Subjects/Methods Infants ( n  = 238) and mothers ( n  = 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum. Results All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08; P  &lt; 0.01). Infant plasma docosahexaenoic acid (DHA) levels were positively associated with maternal DHA levels (0.77 ± 0.09; P  &lt; 0.01) but were lower for twin births (−0.55 ± 0.27; P  = 0.03). Greater birth weight in kilograms (1.00 ± 0.43; P  = 0.02) and higher maternal n-6 PUFA levels (0.20 ± 0.07; P  &lt; 0.01) were positively associated with higher infant n-6 PUFA levels, whereas maternal mono-unsaturated fatty acid (MUFA) levels (−0.26 ± 0.08; P  &lt; 0.01), maternal mid upper arm circumference (MUAC) (−0.22 ± 0.11; P  = 0.04), and male sex (−0.99 ± 0.45; P  = 0.03) were associated with lower infant plasma n-6 PUFA levels. Infant plasma arachidonic acid (AA) levels were positively associated with maternal plasma AA levels (0.38 ± 0.09; P  &lt; 0.01), but inversely associated with twin births (−1.37 ± 0.67; P  = 0.04). Conclusions Greater birth weight and higher maternal plasma PUFA levels at 3 months postpartum were significantly associated with higher infant plasma PUFA levels at 3 months age. Twin births, male sex, and higher maternal MUFA levels were associated with lower infant plasma PUFA levels. Nutrition counseling for optimal intake of PUFA-rich foods, to lactating mothers in resource-limited settings may be beneficial for improved infant health.</description><subject>692/308/174</subject><subject>692/700/1720</subject><subject>692/700/2814</subject><subject>692/700/478/174</subject><subject>Arachidonic acid</subject><subject>Arm circumference</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Birth weight</subject><subject>Births</subject><subject>Clinical Nutrition</subject><subject>Cross-Sectional Studies</subject><subject>Dietary supplements</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids</subject><subject>Epidemiology</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-6</subject><subject>Fatty Acids, Unsaturated</subject><subject>Female</subject><subject>Fish oils</subject><subject>Food intake</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infants (Newborn)</subject><subject>Internal Medicine</subject><subject>Lactation</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Medicine, Experimental</subject><subject>Metabolic Diseases</subject><subject>Neonates</subject><subject>Nutrition</subject><subject>Plasma</subject><subject>Polyunsaturated fatty acids</subject><subject>Postpartum</subject><subject>Public Health</subject><subject>Reorganization and restructuring</subject><subject>Sex</subject><subject>Standard error</subject><subject>Unsaturated fatty acids</subject><subject>Vitamin A</subject><subject>Weight</subject><issn>0954-3007</issn><issn>1476-5640</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kk1vEzEQhi0EoiHwA7iglZBQL1v8tfbuBamqWkCqxCV3a-odJ642dlh7i8Kvx2lK26AgH0b2PPN6ZvQS8p7RM0ZF-zlJJgWtKetqKnlb6xdkxqRWdaMkfUlmtGtkLSjVJ-RNSreUlqTmr8mJYJRL2rEZgSuwOY6pgpSi9ZCxr375vKo2A6Q1VKEWFYS-RFVt4rCdQoI8jfecg5y3FVjfVwPe4ZAqH6oFhN8QPIRycRByekteORgSvnuIc7K4ulxcfKuvf3z9fnF-XdtGiVwrLdoy1A1FqRope4m6B9GJxrUOQDpsVQ-tRd6A66hssXBOO2adptaBmJMve9nNdLPG3mLIIwxmM_o1jFsTwZvDTPArs4x3RiumaWlhTk4fBMb4c8KUzdoni8MAAeOUDOdM8VZISgv68R_0Nk5jKNMZLiTvNGVKPFFLGNCUbcTyr92JmnPFWaua7p6qj1BLDFiajAGdL88H_NkRvpwe194eLfj0rGCFMORVisOUfQzpEGR70I4xpRHd4_IYNTu_mb3fTPGb2fnN6FLz4fnWHyv-GqwAfA-kkgpLHJ9W9X_VP5KQ3rY</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Kamenju, Pili</creator><creator>Hertzmark, Ellen</creator><creator>Kabagambe, Edmond K.</creator><creator>Smith, Emily R.</creator><creator>Muhihi, Alfa</creator><creator>Noor, Ramadhani A.</creator><creator>Mshamu, Salum</creator><creator>Briegleb, Christina</creator><creator>Sudfeld, Christopher</creator><creator>Masanja, Honorati</creator><creator>Fawzi, Wafaie W.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2604-4354</orcidid><orcidid>https://orcid.org/0000-0002-8993-3186</orcidid></search><sort><creationdate>20200101</creationdate><title>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</title><author>Kamenju, Pili ; Hertzmark, Ellen ; Kabagambe, Edmond K. ; Smith, Emily R. ; Muhihi, Alfa ; Noor, Ramadhani A. ; Mshamu, Salum ; Briegleb, Christina ; Sudfeld, Christopher ; Masanja, Honorati ; Fawzi, Wafaie W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/308/174</topic><topic>692/700/1720</topic><topic>692/700/2814</topic><topic>692/700/478/174</topic><topic>Arachidonic acid</topic><topic>Arm circumference</topic><topic>Babies</topic><topic>Baby foods</topic><topic>Birth weight</topic><topic>Births</topic><topic>Clinical Nutrition</topic><topic>Cross-Sectional Studies</topic><topic>Dietary supplements</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids</topic><topic>Epidemiology</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-6</topic><topic>Fatty Acids, Unsaturated</topic><topic>Female</topic><topic>Fish oils</topic><topic>Food intake</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infants (Newborn)</topic><topic>Internal Medicine</topic><topic>Lactation</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Medicine, Experimental</topic><topic>Metabolic Diseases</topic><topic>Neonates</topic><topic>Nutrition</topic><topic>Plasma</topic><topic>Polyunsaturated fatty acids</topic><topic>Postpartum</topic><topic>Public Health</topic><topic>Reorganization and restructuring</topic><topic>Sex</topic><topic>Standard error</topic><topic>Unsaturated fatty acids</topic><topic>Vitamin A</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamenju, Pili</creatorcontrib><creatorcontrib>Hertzmark, Ellen</creatorcontrib><creatorcontrib>Kabagambe, Edmond K.</creatorcontrib><creatorcontrib>Smith, Emily R.</creatorcontrib><creatorcontrib>Muhihi, Alfa</creatorcontrib><creatorcontrib>Noor, Ramadhani A.</creatorcontrib><creatorcontrib>Mshamu, Salum</creatorcontrib><creatorcontrib>Briegleb, Christina</creatorcontrib><creatorcontrib>Sudfeld, Christopher</creatorcontrib><creatorcontrib>Masanja, Honorati</creatorcontrib><creatorcontrib>Fawzi, Wafaie W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamenju, Pili</au><au>Hertzmark, Ellen</au><au>Kabagambe, Edmond K.</au><au>Smith, Emily R.</au><au>Muhihi, Alfa</au><au>Noor, Ramadhani A.</au><au>Mshamu, Salum</au><au>Briegleb, Christina</au><au>Sudfeld, Christopher</au><au>Masanja, Honorati</au><au>Fawzi, Wafaie W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>74</volume><issue>1</issue><spage>97</spage><epage>105</epage><pages>97-105</pages><issn>0954-3007</issn><issn>1476-5640</issn><eissn>1476-5640</eissn><abstract>Background/Objectives To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants. Subjects/Methods Infants ( n  = 238) and mothers ( n  = 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum. Results All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08; P  &lt; 0.01). Infant plasma docosahexaenoic acid (DHA) levels were positively associated with maternal DHA levels (0.77 ± 0.09; P  &lt; 0.01) but were lower for twin births (−0.55 ± 0.27; P  = 0.03). Greater birth weight in kilograms (1.00 ± 0.43; P  = 0.02) and higher maternal n-6 PUFA levels (0.20 ± 0.07; P  &lt; 0.01) were positively associated with higher infant n-6 PUFA levels, whereas maternal mono-unsaturated fatty acid (MUFA) levels (−0.26 ± 0.08; P  &lt; 0.01), maternal mid upper arm circumference (MUAC) (−0.22 ± 0.11; P  = 0.04), and male sex (−0.99 ± 0.45; P  = 0.03) were associated with lower infant plasma n-6 PUFA levels. Infant plasma arachidonic acid (AA) levels were positively associated with maternal plasma AA levels (0.38 ± 0.09; P  &lt; 0.01), but inversely associated with twin births (−1.37 ± 0.67; P  = 0.04). Conclusions Greater birth weight and higher maternal plasma PUFA levels at 3 months postpartum were significantly associated with higher infant plasma PUFA levels at 3 months age. Twin births, male sex, and higher maternal MUFA levels were associated with lower infant plasma PUFA levels. Nutrition counseling for optimal intake of PUFA-rich foods, to lactating mothers in resource-limited settings may be beneficial for improved infant health.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31024091</pmid><doi>10.1038/s41430-019-0428-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2604-4354</orcidid><orcidid>https://orcid.org/0000-0002-8993-3186</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0954-3007
ispartof European journal of clinical nutrition, 2020-01, Vol.74 (1), p.97-105
issn 0954-3007
1476-5640
1476-5640
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7617056
source MEDLINE; Alma/SFX Local Collection
subjects 692/308/174
692/700/1720
692/700/2814
692/700/478/174
Arachidonic acid
Arm circumference
Babies
Baby foods
Birth weight
Births
Clinical Nutrition
Cross-Sectional Studies
Dietary supplements
Docosahexaenoic acid
Docosahexaenoic Acids
Epidemiology
Fatty acids
Fatty Acids, Omega-6
Fatty Acids, Unsaturated
Female
Fish oils
Food intake
Health aspects
Humans
Infant
Infant, Newborn
Infants
Infants (Newborn)
Internal Medicine
Lactation
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Metabolic Diseases
Neonates
Nutrition
Plasma
Polyunsaturated fatty acids
Postpartum
Public Health
Reorganization and restructuring
Sex
Standard error
Unsaturated fatty acids
Vitamin A
Weight
title Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T12%3A45%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factors%20associated%20with%20plasma%20n-3%20and%20n-6%20polyunsaturated%20fatty%20acid%20levels%20in%20Tanzanian%20infants&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Kamenju,%20Pili&rft.date=2020-01-01&rft.volume=74&rft.issue=1&rft.spage=97&rft.epage=105&rft.pages=97-105&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/s41430-019-0428-7&rft_dat=%3Cgale_pubme%3EA621865963%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2342970163&rft_id=info:pmid/31024091&rft_galeid=A621865963&rfr_iscdi=true