Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants
Background/Objectives To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants. Subjects/Methods Infants ( n = 238) and mothers ( n = 193) randomly selected from participants in the neonatal vitamin A supplementation randomized control...
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creator | Kamenju, Pili Hertzmark, Ellen Kabagambe, Edmond K. Smith, Emily R. Muhihi, Alfa Noor, Ramadhani A. Mshamu, Salum Briegleb, Christina Sudfeld, Christopher Masanja, Honorati Fawzi, Wafaie W. |
description | Background/Objectives
To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants.
Subjects/Methods
Infants (
n
= 238) and mothers (
n
= 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum.
Results
All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08;
P
|
doi_str_mv | 10.1038/s41430-019-0428-7 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7617056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A621865963</galeid><sourcerecordid>A621865963</sourcerecordid><originalsourceid>FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</originalsourceid><addsrcrecordid>eNp1kk1vEzEQhi0EoiHwA7iglZBQL1v8tfbuBamqWkCqxCV3a-odJ642dlh7i8Kvx2lK26AgH0b2PPN6ZvQS8p7RM0ZF-zlJJgWtKetqKnlb6xdkxqRWdaMkfUlmtGtkLSjVJ-RNSreUlqTmr8mJYJRL2rEZgSuwOY6pgpSi9ZCxr375vKo2A6Q1VKEWFYS-RFVt4rCdQoI8jfecg5y3FVjfVwPe4ZAqH6oFhN8QPIRycRByekteORgSvnuIc7K4ulxcfKuvf3z9fnF-XdtGiVwrLdoy1A1FqRope4m6B9GJxrUOQDpsVQ-tRd6A66hssXBOO2adptaBmJMve9nNdLPG3mLIIwxmM_o1jFsTwZvDTPArs4x3RiumaWlhTk4fBMb4c8KUzdoni8MAAeOUDOdM8VZISgv68R_0Nk5jKNMZLiTvNGVKPFFLGNCUbcTyr92JmnPFWaua7p6qj1BLDFiajAGdL88H_NkRvpwe194eLfj0rGCFMORVisOUfQzpEGR70I4xpRHd4_IYNTu_mb3fTPGb2fnN6FLz4fnWHyv-GqwAfA-kkgpLHJ9W9X_VP5KQ3rY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2342970163</pqid></control><display><type>article</type><title>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kamenju, Pili ; Hertzmark, Ellen ; Kabagambe, Edmond K. ; Smith, Emily R. ; Muhihi, Alfa ; Noor, Ramadhani A. ; Mshamu, Salum ; Briegleb, Christina ; Sudfeld, Christopher ; Masanja, Honorati ; Fawzi, Wafaie W.</creator><creatorcontrib>Kamenju, Pili ; Hertzmark, Ellen ; Kabagambe, Edmond K. ; Smith, Emily R. ; Muhihi, Alfa ; Noor, Ramadhani A. ; Mshamu, Salum ; Briegleb, Christina ; Sudfeld, Christopher ; Masanja, Honorati ; Fawzi, Wafaie W.</creatorcontrib><description>Background/Objectives
To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants.
Subjects/Methods
Infants (
n
= 238) and mothers (
n
= 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum.
Results
All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08;
P
< 0.01). Infant plasma docosahexaenoic acid (DHA) levels were positively associated with maternal DHA levels (0.77 ± 0.09;
P
< 0.01) but were lower for twin births (−0.55 ± 0.27;
P
= 0.03). Greater birth weight in kilograms (1.00 ± 0.43;
P
= 0.02) and higher maternal n-6 PUFA levels (0.20 ± 0.07;
P
< 0.01) were positively associated with higher infant n-6 PUFA levels, whereas maternal mono-unsaturated fatty acid (MUFA) levels (−0.26 ± 0.08;
P
< 0.01), maternal mid upper arm circumference (MUAC) (−0.22 ± 0.11;
P
= 0.04), and male sex (−0.99 ± 0.45;
P
= 0.03) were associated with lower infant plasma n-6 PUFA levels. Infant plasma arachidonic acid (AA) levels were positively associated with maternal plasma AA levels (0.38 ± 0.09;
P
< 0.01), but inversely associated with twin births (−1.37 ± 0.67;
P
= 0.04).
Conclusions
Greater birth weight and higher maternal plasma PUFA levels at 3 months postpartum were significantly associated with higher infant plasma PUFA levels at 3 months age. Twin births, male sex, and higher maternal MUFA levels were associated with lower infant plasma PUFA levels. Nutrition counseling for optimal intake of PUFA-rich foods, to lactating mothers in resource-limited settings may be beneficial for improved infant health.</description><identifier>ISSN: 0954-3007</identifier><identifier>ISSN: 1476-5640</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-019-0428-7</identifier><identifier>PMID: 31024091</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/700/1720 ; 692/700/2814 ; 692/700/478/174 ; Arachidonic acid ; Arm circumference ; Babies ; Baby foods ; Birth weight ; Births ; Clinical Nutrition ; Cross-Sectional Studies ; Dietary supplements ; Docosahexaenoic acid ; Docosahexaenoic Acids ; Epidemiology ; Fatty acids ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated ; Female ; Fish oils ; Food intake ; Health aspects ; Humans ; Infant ; Infant, Newborn ; Infants ; Infants (Newborn) ; Internal Medicine ; Lactation ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Metabolic Diseases ; Neonates ; Nutrition ; Plasma ; Polyunsaturated fatty acids ; Postpartum ; Public Health ; Reorganization and restructuring ; Sex ; Standard error ; Unsaturated fatty acids ; Vitamin A ; Weight</subject><ispartof>European journal of clinical nutrition, 2020-01, Vol.74 (1), p.97-105</ispartof><rights>Springer Nature Limited 2019</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>Springer Nature Limited 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</citedby><cites>FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</cites><orcidid>0000-0003-2604-4354 ; 0000-0002-8993-3186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31024091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamenju, Pili</creatorcontrib><creatorcontrib>Hertzmark, Ellen</creatorcontrib><creatorcontrib>Kabagambe, Edmond K.</creatorcontrib><creatorcontrib>Smith, Emily R.</creatorcontrib><creatorcontrib>Muhihi, Alfa</creatorcontrib><creatorcontrib>Noor, Ramadhani A.</creatorcontrib><creatorcontrib>Mshamu, Salum</creatorcontrib><creatorcontrib>Briegleb, Christina</creatorcontrib><creatorcontrib>Sudfeld, Christopher</creatorcontrib><creatorcontrib>Masanja, Honorati</creatorcontrib><creatorcontrib>Fawzi, Wafaie W.</creatorcontrib><title>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives
To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants.
Subjects/Methods
Infants (
n
= 238) and mothers (
n
= 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum.
Results
All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08;
P
< 0.01). Infant plasma docosahexaenoic acid (DHA) levels were positively associated with maternal DHA levels (0.77 ± 0.09;
P
< 0.01) but were lower for twin births (−0.55 ± 0.27;
P
= 0.03). Greater birth weight in kilograms (1.00 ± 0.43;
P
= 0.02) and higher maternal n-6 PUFA levels (0.20 ± 0.07;
P
< 0.01) were positively associated with higher infant n-6 PUFA levels, whereas maternal mono-unsaturated fatty acid (MUFA) levels (−0.26 ± 0.08;
P
< 0.01), maternal mid upper arm circumference (MUAC) (−0.22 ± 0.11;
P
= 0.04), and male sex (−0.99 ± 0.45;
P
= 0.03) were associated with lower infant plasma n-6 PUFA levels. Infant plasma arachidonic acid (AA) levels were positively associated with maternal plasma AA levels (0.38 ± 0.09;
P
< 0.01), but inversely associated with twin births (−1.37 ± 0.67;
P
= 0.04).
Conclusions
Greater birth weight and higher maternal plasma PUFA levels at 3 months postpartum were significantly associated with higher infant plasma PUFA levels at 3 months age. Twin births, male sex, and higher maternal MUFA levels were associated with lower infant plasma PUFA levels. Nutrition counseling for optimal intake of PUFA-rich foods, to lactating mothers in resource-limited settings may be beneficial for improved infant health.</description><subject>692/308/174</subject><subject>692/700/1720</subject><subject>692/700/2814</subject><subject>692/700/478/174</subject><subject>Arachidonic acid</subject><subject>Arm circumference</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Birth weight</subject><subject>Births</subject><subject>Clinical Nutrition</subject><subject>Cross-Sectional Studies</subject><subject>Dietary supplements</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids</subject><subject>Epidemiology</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-6</subject><subject>Fatty Acids, Unsaturated</subject><subject>Female</subject><subject>Fish oils</subject><subject>Food intake</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infants (Newborn)</subject><subject>Internal Medicine</subject><subject>Lactation</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Metabolic Diseases</subject><subject>Neonates</subject><subject>Nutrition</subject><subject>Plasma</subject><subject>Polyunsaturated fatty acids</subject><subject>Postpartum</subject><subject>Public Health</subject><subject>Reorganization and restructuring</subject><subject>Sex</subject><subject>Standard error</subject><subject>Unsaturated fatty acids</subject><subject>Vitamin A</subject><subject>Weight</subject><issn>0954-3007</issn><issn>1476-5640</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kk1vEzEQhi0EoiHwA7iglZBQL1v8tfbuBamqWkCqxCV3a-odJ642dlh7i8Kvx2lK26AgH0b2PPN6ZvQS8p7RM0ZF-zlJJgWtKetqKnlb6xdkxqRWdaMkfUlmtGtkLSjVJ-RNSreUlqTmr8mJYJRL2rEZgSuwOY6pgpSi9ZCxr375vKo2A6Q1VKEWFYS-RFVt4rCdQoI8jfecg5y3FVjfVwPe4ZAqH6oFhN8QPIRycRByekteORgSvnuIc7K4ulxcfKuvf3z9fnF-XdtGiVwrLdoy1A1FqRope4m6B9GJxrUOQDpsVQ-tRd6A66hssXBOO2adptaBmJMve9nNdLPG3mLIIwxmM_o1jFsTwZvDTPArs4x3RiumaWlhTk4fBMb4c8KUzdoni8MAAeOUDOdM8VZISgv68R_0Nk5jKNMZLiTvNGVKPFFLGNCUbcTyr92JmnPFWaua7p6qj1BLDFiajAGdL88H_NkRvpwe194eLfj0rGCFMORVisOUfQzpEGR70I4xpRHd4_IYNTu_mb3fTPGb2fnN6FLz4fnWHyv-GqwAfA-kkgpLHJ9W9X_VP5KQ3rY</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Kamenju, Pili</creator><creator>Hertzmark, Ellen</creator><creator>Kabagambe, Edmond K.</creator><creator>Smith, Emily R.</creator><creator>Muhihi, Alfa</creator><creator>Noor, Ramadhani A.</creator><creator>Mshamu, Salum</creator><creator>Briegleb, Christina</creator><creator>Sudfeld, Christopher</creator><creator>Masanja, Honorati</creator><creator>Fawzi, Wafaie W.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2604-4354</orcidid><orcidid>https://orcid.org/0000-0002-8993-3186</orcidid></search><sort><creationdate>20200101</creationdate><title>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</title><author>Kamenju, Pili ; Hertzmark, Ellen ; Kabagambe, Edmond K. ; Smith, Emily R. ; Muhihi, Alfa ; Noor, Ramadhani A. ; Mshamu, Salum ; Briegleb, Christina ; Sudfeld, Christopher ; Masanja, Honorati ; Fawzi, Wafaie W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-6738103b0e46544d4e7da3935f8faa4fe86da8ce25af9048ee46f7f1cf70cfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/308/174</topic><topic>692/700/1720</topic><topic>692/700/2814</topic><topic>692/700/478/174</topic><topic>Arachidonic acid</topic><topic>Arm circumference</topic><topic>Babies</topic><topic>Baby foods</topic><topic>Birth weight</topic><topic>Births</topic><topic>Clinical Nutrition</topic><topic>Cross-Sectional Studies</topic><topic>Dietary supplements</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids</topic><topic>Epidemiology</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-6</topic><topic>Fatty Acids, Unsaturated</topic><topic>Female</topic><topic>Fish oils</topic><topic>Food intake</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infants (Newborn)</topic><topic>Internal Medicine</topic><topic>Lactation</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Metabolic Diseases</topic><topic>Neonates</topic><topic>Nutrition</topic><topic>Plasma</topic><topic>Polyunsaturated fatty acids</topic><topic>Postpartum</topic><topic>Public Health</topic><topic>Reorganization and restructuring</topic><topic>Sex</topic><topic>Standard error</topic><topic>Unsaturated fatty acids</topic><topic>Vitamin A</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamenju, Pili</creatorcontrib><creatorcontrib>Hertzmark, Ellen</creatorcontrib><creatorcontrib>Kabagambe, Edmond K.</creatorcontrib><creatorcontrib>Smith, Emily R.</creatorcontrib><creatorcontrib>Muhihi, Alfa</creatorcontrib><creatorcontrib>Noor, Ramadhani A.</creatorcontrib><creatorcontrib>Mshamu, Salum</creatorcontrib><creatorcontrib>Briegleb, Christina</creatorcontrib><creatorcontrib>Sudfeld, Christopher</creatorcontrib><creatorcontrib>Masanja, Honorati</creatorcontrib><creatorcontrib>Fawzi, Wafaie W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamenju, Pili</au><au>Hertzmark, Ellen</au><au>Kabagambe, Edmond K.</au><au>Smith, Emily R.</au><au>Muhihi, Alfa</au><au>Noor, Ramadhani A.</au><au>Mshamu, Salum</au><au>Briegleb, Christina</au><au>Sudfeld, Christopher</au><au>Masanja, Honorati</au><au>Fawzi, Wafaie W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>74</volume><issue>1</issue><spage>97</spage><epage>105</epage><pages>97-105</pages><issn>0954-3007</issn><issn>1476-5640</issn><eissn>1476-5640</eissn><abstract>Background/Objectives
To identify factors associated with plasma polyunsaturated fatty acid (PUFA) levels among 3-month-old Tanzanian infants.
Subjects/Methods
Infants (
n
= 238) and mothers (
n
= 193) randomly selected from participants in the neonatal vitamin A supplementation randomized controlled trial. A cross-sectional study of maternal–infant pairs at 3 months postpartum.
Results
All infant total, n-3, n-6, and individual PUFA levels were correlated with maternal levels. Infant plasma n-3 PUFA levels were higher when maternal n-3 PUFA levels were higher (mean difference in infant % fatty acid per unit increase in maternal levels ± standard error: 0.79 ± 0.08;
P
< 0.01). Infant plasma docosahexaenoic acid (DHA) levels were positively associated with maternal DHA levels (0.77 ± 0.09;
P
< 0.01) but were lower for twin births (−0.55 ± 0.27;
P
= 0.03). Greater birth weight in kilograms (1.00 ± 0.43;
P
= 0.02) and higher maternal n-6 PUFA levels (0.20 ± 0.07;
P
< 0.01) were positively associated with higher infant n-6 PUFA levels, whereas maternal mono-unsaturated fatty acid (MUFA) levels (−0.26 ± 0.08;
P
< 0.01), maternal mid upper arm circumference (MUAC) (−0.22 ± 0.11;
P
= 0.04), and male sex (−0.99 ± 0.45;
P
= 0.03) were associated with lower infant plasma n-6 PUFA levels. Infant plasma arachidonic acid (AA) levels were positively associated with maternal plasma AA levels (0.38 ± 0.09;
P
< 0.01), but inversely associated with twin births (−1.37 ± 0.67;
P
= 0.04).
Conclusions
Greater birth weight and higher maternal plasma PUFA levels at 3 months postpartum were significantly associated with higher infant plasma PUFA levels at 3 months age. Twin births, male sex, and higher maternal MUFA levels were associated with lower infant plasma PUFA levels. Nutrition counseling for optimal intake of PUFA-rich foods, to lactating mothers in resource-limited settings may be beneficial for improved infant health.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31024091</pmid><doi>10.1038/s41430-019-0428-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2604-4354</orcidid><orcidid>https://orcid.org/0000-0002-8993-3186</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
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ispartof | European journal of clinical nutrition, 2020-01, Vol.74 (1), p.97-105 |
issn | 0954-3007 1476-5640 1476-5640 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7617056 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | 692/308/174 692/700/1720 692/700/2814 692/700/478/174 Arachidonic acid Arm circumference Babies Baby foods Birth weight Births Clinical Nutrition Cross-Sectional Studies Dietary supplements Docosahexaenoic acid Docosahexaenoic Acids Epidemiology Fatty acids Fatty Acids, Omega-6 Fatty Acids, Unsaturated Female Fish oils Food intake Health aspects Humans Infant Infant, Newborn Infants Infants (Newborn) Internal Medicine Lactation Male Medical research Medicine Medicine & Public Health Medicine, Experimental Metabolic Diseases Neonates Nutrition Plasma Polyunsaturated fatty acids Postpartum Public Health Reorganization and restructuring Sex Standard error Unsaturated fatty acids Vitamin A Weight |
title | Factors associated with plasma n-3 and n-6 polyunsaturated fatty acid levels in Tanzanian infants |
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