Microbiome diversity protects against pathogens by nutrient blocking

The human gut microbiome plays an important role in resisting colonization of the host by pathogens, but we lack the ability to predict which communities will be protective. We studied how human gut bacteria influence colonization of two major bacterial pathogens, both in vitro and in gnotobiotic mi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2023-12, Vol.382 (6676), p.eadj3502-eadj3502
Hauptverfasser:	Spragge, Frances, Bakkeren, Erik, Jahn, Martin T, B N Araujo, Elizete, Pearson, Claire F, Wang, Xuedan, Pankhurst, Louise, Cunrath, Olivier, Foster, Kevin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bacteria Bacteriology Blocking Colonization Community composition Community Relations Composition E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Gastrointestinal Microbiome Germ-Free Life Germfree Gnotobiotic Holistic Approach Host-Pathogen Interactions Human health and pathology Humans Hépatology and Gastroenterology Infectious diseases Intestinal microflora Introduced species Klebsiella Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - genetics Klebsiella pneumoniae - growth & development Klebsiella pneumoniae - metabolism Land Settlement Life Sciences Metabolism Mice Microbiology and Parasitology Microbiomes Microbiota Microorganisms Nutrient utilization Nutrients Nutrients - metabolism Pathogens Principles Protected species Salmonella Infections - microbiology Salmonella Typhimurium Salmonella typhimurium - genetics Salmonella typhimurium - growth & development Salmonella typhimurium - metabolism Species Symbionts Symbiosis
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