Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

Unbalanced immune responses to pathogens can be life-threatening although the underlying regulatory mechanisms remain unknown. Here, we show a hypoxia-inducible factor 1α-dependent microRNA (miR)-210 up-regulation in monocytes and macrophages upon pathogen interaction. MiR-210 knockout in the hemato...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Science advances 2021-05, Vol.7 (19)
Hauptverfasser:	Virga, Federico, Cappellesso, Federica, Stijlemans, Benoit, Henze, Anne-Theres, Trotta, Rosa, Van Audenaerde, Jonas, Mirchandani, Ananda S, Sanchez-Garcia, Manuel A, Vandewalle, Jolien, Orso, Francesca, Riera-Domingo, Carla, Griffa, Alberto, Ivan, Cristina, Smits, Evelien, Laoui, Damya, Martelli, Fabio, Langouche, Lies, Van den Berghe, Greet, Feron, Olivier, Ghesquière, Bart, Prenen, Hans, Libert, Claude, Walmsley, Sarah R, Corbet, Cyril, Van Ginderachter, Jo A, Ivan, Mircea, Taverna, Daniela, Mazzone, Massimiliano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Inflammation - genetics Inflammation - metabolism Macrophages - metabolism Mice MicroRNAs - genetics MicroRNAs - metabolism Monocytes - metabolism Sepsis - genetics Sepsis - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!