Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor

The M5 muscarinic acetylcholine receptor (mAChR) has emerged as an exciting therapeutic target for the treatment of addiction and behavioral disorders. This has been in part due to promising preclinical studies with the M5 mAChR selective negative allosteric modulator (NAM), ML375. The binding site...

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Veröffentlicht in:	ACS chemical neuroscience 2021-08, Vol.12 (16), p.3112-3123
Hauptverfasser:	Burger, Wessel A. C, Gentry, Patrick R, Berizzi, Alice E, Vuckovic, Ziva, van der Westhuizen, Emma T, Thompson, Geoff, Yeasmin, Mahmuda, Lindsley, Craig W, Sexton, Patrick M, Langmead, Christopher J, Tobin, Andrew B, Christopoulos, Arthur, Valant, Celine, Thal, David M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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