Structural basis of human U5 snRNP late biogenesis and recycling

Pre-mRNA splicing by the spliceosome requires the biogenesis and recycling of its small nuclear ribonucleoprotein (snRNP) complexes, which are consumed in each round of splicing. The human U5 snRNP is the ~1 MDa ‘heart’ of the spliceosome and is recycled through an unknown mechanism involving major...

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Veröffentlicht in:	Nature structural & molecular biology 2024-05, Vol.31 (5), p.747-751
Hauptverfasser:	Riabov Bassat, Daria, Visanpattanasin, Supapat, Vorländer, Matthias K., Fin, Laura, Phillips, Alexander W., Plaschka, Clemens
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1645/1792 631/535/1258/1259 Architecture Biochemistry Biological Microscopy Biomedical and Life Sciences Biosynthesis Brief Communication Chaperones Communication Cryoelectron Microscopy Electron microscopy Humans Life Sciences Membrane Biology Microscopy Models, Molecular Molecular biology Molecular Chaperones - chemistry Molecular Chaperones - metabolism mRNA Protein Conformation Protein Structure Proteins Recycling Ribonucleoprotein, U5 Small Nuclear - chemistry Ribonucleoprotein, U5 Small Nuclear - genetics Ribonucleoprotein, U5 Small Nuclear - metabolism Ribonucleoproteins (small nuclear) RNA Splicing RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Spliceosomes - chemistry Spliceosomes - metabolism Spliceosomes - ultrastructure Transmission electron microscopy
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