The transcription factor ZEB2 drives the formation of age-associated B cells

Age-associated B cells (ABCs) accumulate during infection, aging, and autoimmunity, contributing to lupus pathogenesis. In this study, we screened for transcription factors driving ABC formation and found that zinc finger E-box binding homeobox 2 (ZEB2) is required for human and mouse ABC differenti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2024-01, Vol.383 (6681), p.413-421
Hauptverfasser:	Dai, Dai, Gu, Shuangshuang, Han, Xiaxia, Ding, Huihua, Jiang, Yang, Zhang, Xiaoou, Yao, Chao, Hong, Soonmin, Zhang, Jinsong, Shen, Yiwei, Hou, Guojun, Qu, Bo, Zhou, Haibo, Qin, Yuting, He, Yuke, Ma, Jianyang, Yin, Zhihua, Ye, Zhizhong, Qian, Jie, Jiang, Qian, Wu, Lihua, Guo, Qiang, Chen, Sheng, Huang, Chuanxin, Kottyan, Leah C, Weirauch, Matthew T, Vinuesa, Carola G, Shen, Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - immunology Animals Autoimmune diseases Autoimmunity - genetics B-Lymphocytes - cytology B-Lymphocytes - metabolism CD11c antigen Cell Differentiation - genetics Cell Lineage - genetics Chronic conditions Disease Models, Animal Female Gene Expression Regulation Germinal centers Haploinsufficiency Humans Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lymphocytes B MEF2 Transcription Factors - genetics MEF2 Transcription Factors - metabolism Mice Multiple sclerosis Pathogenesis Pathogenicity Pathogens Phagocytes Phenotypes Systemic lupus erythematosus Zinc Finger E-box Binding Homeobox 2 - genetics Zinc Finger E-box Binding Homeobox 2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!