The course of fatigue during the development of rheumatoid arthritis and its relation with inflammation: a longitudinal study
•Fatigue in patients with clinically suspect arthralgia (CSA) increased gradually towards development of rheumatoid arthritis (RA).•In contrast, fatigue decreased in CSA-patients who did not develop RA.•ACPA-positive CSA-patients reported lower levels of fatigue than ACPA-negative CSA, but the assoc...
Gespeichert in:
| Veröffentlicht in: | Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2022-11, Vol.89 (6), p.105432-105432, Article 105432 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 105432 |
|---|---|
| container_issue | 6 |
| container_start_page | 105432 |
| container_title | Joint, bone, spine : revue du rhumatisme |
| container_volume | 89 |
| creator | Khidir, Sarah J.H. Wouters, Fenne van der Helm-van Mil, Annette H.M. van Mulligen, Elise |
| description | •Fatigue in patients with clinically suspect arthralgia (CSA) increased gradually towards development of rheumatoid arthritis (RA).•In contrast, fatigue decreased in CSA-patients who did not develop RA.•ACPA-positive CSA-patients reported lower levels of fatigue than ACPA-negative CSA, but the association between fatigue and inflammation was stronger in ACPA-positive compared to ACPA-negative CSA.•Fatigue at CSA-onset was explained to a larger extent than fatigue at RA-diagnosis.•This may imply a ‘phase-dependent relation’ between inflammation and fatigue.
Fatigue is a prominent and disabling symptom in patients with rheumatoid arthritis (RA), that is only partially explained by inflammation and responds poorly to DMARD-therapy. We hypothesized that inflammation explains fatigue to a larger extent in the phase of clinically suspect arthralgia (CSA), when persistent clinical arthritis is still absent and fatigue has not yet become chronic. We therefore studied the course of fatigue in CSA during progression to RA and the association with inflammation at CSA-onset and at RA-diagnosis.
600 consecutive CSA-patients were followed for RA-development. Additionally, 710 early RA-patients were studied at diagnosis. Fatigue was assessed every study visit and expressed on a 0-100 scale. Inflammation was measured with the DAS44-CRP, with and without including subclinical inflammation. The course of fatigue over time was studied with linear mixed models. Associations between fatigue and inflammation were studied with linear regression. Analyses were stratified by ACPA-status.
In 88 CSA-patients who developed RA, pre-arthritis fatigue-levels increased gradually with 7 points/year, towards 48 (95%CI=41-55) at RA-development (P=ns). Fatigue decreased in CSA-patients who did not develop RA (4 points/year, P |
| doi_str_mv | 10.1016/j.jbspin.2022.105432 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7615874</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1297319X22000926</els_id><sourcerecordid>2684099730</sourcerecordid><originalsourceid>FETCH-LOGICAL-c463t-23e5389940063906cad32a380f06b95e690a89ffbca791d325499b3f918e047e3</originalsourceid><addsrcrecordid>eNp9UcuO1DAQjBCIfcAfIOQjlwyOHccxByS0AhZpJS6LxM1ynM6kR4492M6gPfDveJhlgQunbnVVVz-qql40dNPQpnu92-yGtEe_YZSxUhItZ4-q80bKvpZMtI9LzpSseaO-nlUXKe0opZyJ7ml1xoWUUghxXv24nYHYsMYEJExkMhm3K5Bxjei3JBdwhAO4sF_A5yMjzrAuJgcciYl5jpgxEeNHgjmRCK4IBE--Y54J-smZZflVeUMMccFvMa8jeuNIKsnds-rJZFyC5_fxsvry4f3t1XV98_njp6t3N7VtO55rxkHwXqmW0o4r2lkzcmZ4TyfaDUpAp6jp1TQN1kjVFEy0Sg18Uk0PtJXAL6u3J939Oiww2nJLNE7vIy4m3ulgUP-LeJz1Nhy07BrRy7YIvLoXiOHbCinrBZMF54yHsCbNur6lSklOC7U9UW0MKUWYHsY0VB-d0zt9ck4fndMn50rby79XfGj6bdWfG6A86oAQdbII3sKIEWzWY8D_T_gJxL2vPw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2684099730</pqid></control><display><type>article</type><title>The course of fatigue during the development of rheumatoid arthritis and its relation with inflammation: a longitudinal study</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Khidir, Sarah J.H. ; Wouters, Fenne ; van der Helm-van Mil, Annette H.M. ; van Mulligen, Elise</creator><creatorcontrib>Khidir, Sarah J.H. ; Wouters, Fenne ; van der Helm-van Mil, Annette H.M. ; van Mulligen, Elise</creatorcontrib><description>•Fatigue in patients with clinically suspect arthralgia (CSA) increased gradually towards development of rheumatoid arthritis (RA).•In contrast, fatigue decreased in CSA-patients who did not develop RA.•ACPA-positive CSA-patients reported lower levels of fatigue than ACPA-negative CSA, but the association between fatigue and inflammation was stronger in ACPA-positive compared to ACPA-negative CSA.•Fatigue at CSA-onset was explained to a larger extent than fatigue at RA-diagnosis.•This may imply a ‘phase-dependent relation’ between inflammation and fatigue.
Fatigue is a prominent and disabling symptom in patients with rheumatoid arthritis (RA), that is only partially explained by inflammation and responds poorly to DMARD-therapy. We hypothesized that inflammation explains fatigue to a larger extent in the phase of clinically suspect arthralgia (CSA), when persistent clinical arthritis is still absent and fatigue has not yet become chronic. We therefore studied the course of fatigue in CSA during progression to RA and the association with inflammation at CSA-onset and at RA-diagnosis.
600 consecutive CSA-patients were followed for RA-development. Additionally, 710 early RA-patients were studied at diagnosis. Fatigue was assessed every study visit and expressed on a 0-100 scale. Inflammation was measured with the DAS44-CRP, with and without including subclinical inflammation. The course of fatigue over time was studied with linear mixed models. Associations between fatigue and inflammation were studied with linear regression. Analyses were stratified by ACPA-status.
In 88 CSA-patients who developed RA, pre-arthritis fatigue-levels increased gradually with 7 points/year, towards 48 (95%CI=41-55) at RA-development (P=ns). Fatigue decreased in CSA-patients who did not develop RA (4 points/year, P<0.001). At CSA-onset, inflammation was associated with fatigue (β=18, meaning 18 points more fatigue per point increase DAS-score, P<0.01). This association was stronger than at RA-diagnosis (β=5, P<0.001). Fatigue-levels were lower in ACPA-positive pre-RA, but its association with inflammation was stronger compared to ACPA-negative pre-RA.
Fatigue increased gradually during progression from arthralgia to clinical arthritis, and fatigue was better explained by inflammation in CSA than in RA. This implies a ‘phase-dependent relation’ between inflammation and fatigue.</description><identifier>ISSN: 1297-319X</identifier><identifier>EISSN: 1778-7254</identifier><identifier>DOI: 10.1016/j.jbspin.2022.105432</identifier><identifier>PMID: 35777555</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Arthralgia - complications ; Arthralgia - etiology ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - diagnosis ; Clinically suspect arthralgia ; Disease Progression ; Fatigue ; Fatigue - etiology ; Humans ; Inflammation ; Longitudinal Studies ; Patient reported outcomes ; Rheumatoid arthritis ; Time course</subject><ispartof>Joint, bone, spine : revue du rhumatisme, 2022-11, Vol.89 (6), p.105432-105432, Article 105432</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-23e5389940063906cad32a380f06b95e690a89ffbca791d325499b3f918e047e3</citedby><cites>FETCH-LOGICAL-c463t-23e5389940063906cad32a380f06b95e690a89ffbca791d325499b3f918e047e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jbspin.2022.105432$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,3551,27925,27926,45996</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35777555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khidir, Sarah J.H.</creatorcontrib><creatorcontrib>Wouters, Fenne</creatorcontrib><creatorcontrib>van der Helm-van Mil, Annette H.M.</creatorcontrib><creatorcontrib>van Mulligen, Elise</creatorcontrib><title>The course of fatigue during the development of rheumatoid arthritis and its relation with inflammation: a longitudinal study</title><title>Joint, bone, spine : revue du rhumatisme</title><addtitle>Joint Bone Spine</addtitle><description>•Fatigue in patients with clinically suspect arthralgia (CSA) increased gradually towards development of rheumatoid arthritis (RA).•In contrast, fatigue decreased in CSA-patients who did not develop RA.•ACPA-positive CSA-patients reported lower levels of fatigue than ACPA-negative CSA, but the association between fatigue and inflammation was stronger in ACPA-positive compared to ACPA-negative CSA.•Fatigue at CSA-onset was explained to a larger extent than fatigue at RA-diagnosis.•This may imply a ‘phase-dependent relation’ between inflammation and fatigue.
Fatigue is a prominent and disabling symptom in patients with rheumatoid arthritis (RA), that is only partially explained by inflammation and responds poorly to DMARD-therapy. We hypothesized that inflammation explains fatigue to a larger extent in the phase of clinically suspect arthralgia (CSA), when persistent clinical arthritis is still absent and fatigue has not yet become chronic. We therefore studied the course of fatigue in CSA during progression to RA and the association with inflammation at CSA-onset and at RA-diagnosis.
600 consecutive CSA-patients were followed for RA-development. Additionally, 710 early RA-patients were studied at diagnosis. Fatigue was assessed every study visit and expressed on a 0-100 scale. Inflammation was measured with the DAS44-CRP, with and without including subclinical inflammation. The course of fatigue over time was studied with linear mixed models. Associations between fatigue and inflammation were studied with linear regression. Analyses were stratified by ACPA-status.
In 88 CSA-patients who developed RA, pre-arthritis fatigue-levels increased gradually with 7 points/year, towards 48 (95%CI=41-55) at RA-development (P=ns). Fatigue decreased in CSA-patients who did not develop RA (4 points/year, P<0.001). At CSA-onset, inflammation was associated with fatigue (β=18, meaning 18 points more fatigue per point increase DAS-score, P<0.01). This association was stronger than at RA-diagnosis (β=5, P<0.001). Fatigue-levels were lower in ACPA-positive pre-RA, but its association with inflammation was stronger compared to ACPA-negative pre-RA.
Fatigue increased gradually during progression from arthralgia to clinical arthritis, and fatigue was better explained by inflammation in CSA than in RA. This implies a ‘phase-dependent relation’ between inflammation and fatigue.</description><subject>Arthralgia - complications</subject><subject>Arthralgia - etiology</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Clinically suspect arthralgia</subject><subject>Disease Progression</subject><subject>Fatigue</subject><subject>Fatigue - etiology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Longitudinal Studies</subject><subject>Patient reported outcomes</subject><subject>Rheumatoid arthritis</subject><subject>Time course</subject><issn>1297-319X</issn><issn>1778-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuO1DAQjBCIfcAfIOQjlwyOHccxByS0AhZpJS6LxM1ynM6kR4492M6gPfDveJhlgQunbnVVVz-qql40dNPQpnu92-yGtEe_YZSxUhItZ4-q80bKvpZMtI9LzpSseaO-nlUXKe0opZyJ7ml1xoWUUghxXv24nYHYsMYEJExkMhm3K5Bxjei3JBdwhAO4sF_A5yMjzrAuJgcciYl5jpgxEeNHgjmRCK4IBE--Y54J-smZZflVeUMMccFvMa8jeuNIKsnds-rJZFyC5_fxsvry4f3t1XV98_njp6t3N7VtO55rxkHwXqmW0o4r2lkzcmZ4TyfaDUpAp6jp1TQN1kjVFEy0Sg18Uk0PtJXAL6u3J939Oiww2nJLNE7vIy4m3ulgUP-LeJz1Nhy07BrRy7YIvLoXiOHbCinrBZMF54yHsCbNur6lSklOC7U9UW0MKUWYHsY0VB-d0zt9ck4fndMn50rby79XfGj6bdWfG6A86oAQdbII3sKIEWzWY8D_T_gJxL2vPw</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Khidir, Sarah J.H.</creator><creator>Wouters, Fenne</creator><creator>van der Helm-van Mil, Annette H.M.</creator><creator>van Mulligen, Elise</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221101</creationdate><title>The course of fatigue during the development of rheumatoid arthritis and its relation with inflammation: a longitudinal study</title><author>Khidir, Sarah J.H. ; Wouters, Fenne ; van der Helm-van Mil, Annette H.M. ; van Mulligen, Elise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-23e5389940063906cad32a380f06b95e690a89ffbca791d325499b3f918e047e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arthralgia - complications</topic><topic>Arthralgia - etiology</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Clinically suspect arthralgia</topic><topic>Disease Progression</topic><topic>Fatigue</topic><topic>Fatigue - etiology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Longitudinal Studies</topic><topic>Patient reported outcomes</topic><topic>Rheumatoid arthritis</topic><topic>Time course</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khidir, Sarah J.H.</creatorcontrib><creatorcontrib>Wouters, Fenne</creatorcontrib><creatorcontrib>van der Helm-van Mil, Annette H.M.</creatorcontrib><creatorcontrib>van Mulligen, Elise</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khidir, Sarah J.H.</au><au>Wouters, Fenne</au><au>van der Helm-van Mil, Annette H.M.</au><au>van Mulligen, Elise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The course of fatigue during the development of rheumatoid arthritis and its relation with inflammation: a longitudinal study</atitle><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle><addtitle>Joint Bone Spine</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>89</volume><issue>6</issue><spage>105432</spage><epage>105432</epage><pages>105432-105432</pages><artnum>105432</artnum><issn>1297-319X</issn><eissn>1778-7254</eissn><abstract>•Fatigue in patients with clinically suspect arthralgia (CSA) increased gradually towards development of rheumatoid arthritis (RA).•In contrast, fatigue decreased in CSA-patients who did not develop RA.•ACPA-positive CSA-patients reported lower levels of fatigue than ACPA-negative CSA, but the association between fatigue and inflammation was stronger in ACPA-positive compared to ACPA-negative CSA.•Fatigue at CSA-onset was explained to a larger extent than fatigue at RA-diagnosis.•This may imply a ‘phase-dependent relation’ between inflammation and fatigue.
Fatigue is a prominent and disabling symptom in patients with rheumatoid arthritis (RA), that is only partially explained by inflammation and responds poorly to DMARD-therapy. We hypothesized that inflammation explains fatigue to a larger extent in the phase of clinically suspect arthralgia (CSA), when persistent clinical arthritis is still absent and fatigue has not yet become chronic. We therefore studied the course of fatigue in CSA during progression to RA and the association with inflammation at CSA-onset and at RA-diagnosis.
600 consecutive CSA-patients were followed for RA-development. Additionally, 710 early RA-patients were studied at diagnosis. Fatigue was assessed every study visit and expressed on a 0-100 scale. Inflammation was measured with the DAS44-CRP, with and without including subclinical inflammation. The course of fatigue over time was studied with linear mixed models. Associations between fatigue and inflammation were studied with linear regression. Analyses were stratified by ACPA-status.
In 88 CSA-patients who developed RA, pre-arthritis fatigue-levels increased gradually with 7 points/year, towards 48 (95%CI=41-55) at RA-development (P=ns). Fatigue decreased in CSA-patients who did not develop RA (4 points/year, P<0.001). At CSA-onset, inflammation was associated with fatigue (β=18, meaning 18 points more fatigue per point increase DAS-score, P<0.01). This association was stronger than at RA-diagnosis (β=5, P<0.001). Fatigue-levels were lower in ACPA-positive pre-RA, but its association with inflammation was stronger compared to ACPA-negative pre-RA.
Fatigue increased gradually during progression from arthralgia to clinical arthritis, and fatigue was better explained by inflammation in CSA than in RA. This implies a ‘phase-dependent relation’ between inflammation and fatigue.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>35777555</pmid><doi>10.1016/j.jbspin.2022.105432</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1297-319X |
| ispartof | Joint, bone, spine : revue du rhumatisme, 2022-11, Vol.89 (6), p.105432-105432, Article 105432 |
| issn | 1297-319X 1778-7254 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7615874 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Arthralgia - complications Arthralgia - etiology Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - diagnosis Clinically suspect arthralgia Disease Progression Fatigue Fatigue - etiology Humans Inflammation Longitudinal Studies Patient reported outcomes Rheumatoid arthritis Time course |
| title | The course of fatigue during the development of rheumatoid arthritis and its relation with inflammation: a longitudinal study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T13%3A47%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20course%20of%20fatigue%20during%20the%20development%20of%20rheumatoid%20arthritis%20and%20its%20relation%20with%20inflammation:%20a%20longitudinal%20study&rft.jtitle=Joint,%20bone,%20spine%20:%20revue%20du%20rhumatisme&rft.au=Khidir,%20Sarah%20J.H.&rft.date=2022-11-01&rft.volume=89&rft.issue=6&rft.spage=105432&rft.epage=105432&rft.pages=105432-105432&rft.artnum=105432&rft.issn=1297-319X&rft.eissn=1778-7254&rft_id=info:doi/10.1016/j.jbspin.2022.105432&rft_dat=%3Cproquest_pubme%3E2684099730%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2684099730&rft_id=info:pmid/35777555&rft_els_id=S1297319X22000926&rfr_iscdi=true |