Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism result in histone modifications and changes to gene expression that affect cardiac fu...

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Veröffentlicht in:	Nature Cardiovascular Research 2023-12, Vol.2 (12), p.1221-1245
Hauptverfasser:	Park, Kyung Chan, Crump, Nicholas T, Louwman, Niamh, Krywawych, Steve, Cheong, Yuen Jian, Vendrell, Iolanda, Gill, Eleanor K, Gunadasa-Rohling, Mala, Ford, Kerrie L, Hauton, David, Fournier, Marjorie, Pires, Elisabete, Watson, Lydia, Roseman, Gerald, Holder, James, Koschinski, Andreas, Carnicer, Ricardo, Curtis, M Kate, Zaccolo, Manuela, Hulikova, Alzbeta, Fischer, Roman, Kramer, Holger B, McCullagh, James S O, Trefely, Sophie, Milne, Thomas A, Swietach, Pawel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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