Influence of cannabis use on incidence of psychosis in people at clinical high risk
Aims Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association b...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2023-09, Vol.77 (9), p.469-477 |
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| creator | Chester, Lucy A. Valmaggia, Lucia R. Kempton, Matthew J. Chesney, Edward Oliver, Dominic Hedges, Emily P. Klatsa, Elise Stahl, Daniel Gaag, Mark Haan, Lieuwe Nelson, Barnaby McGorry, Patrick Amminger, G. Paul Riecher‐Rössler, Anita Studerus, Erich Bressan, Rodrigo Barrantes‐Vidal, Neus Krebs, Marie‐Odile Glenthøj, Birte Nordentoft, Merete Ruhrmann, Stephan Sachs, Gabriele McGuire, Philip McGuire, Philip Valmaggia, Lucia R. Kempton, Matthew J. Calem, Maria Tognin, Stefania Modinos, Gemma Haan, Lieuwe der Gaag, Mark Velthorst, Eva Kraan, Tamar C. Dam, Daniella S. Burger, Nadine Nelson, Barnaby McGorry, Patrick Amminger, G Paul Pantelis, Christos Politis, Athena Goodall, Joanne Riecher‐Rössler, Anita Borgwardt, Stefan Studerus, Erich Bressan, Rodrigo Gadelha, Ary Brietzke, Elisa Asevedo, Graccielle Asevedo, Elson Zugman, Andre Barrantes‐Vidal, Neus Domínguez‐Martínez, Tecelli Racioppi, Anna Kwapil, Thomas R. Monsonet, Manel Hinojosa, Lídia Kazes, Mathilde Daban, Claire Bourgin, Julie Gay, Olivier Mam‐Lam‐Fook, Célia Krebs, Marie‐Odile Nordholm, Dorte Randers, Lasse Krakauer, Kristine Glenthøj, Louise Glenthøj, Birte Nordentoft, Merete Ruhrmann, Stephan Gebhard, Dominika Arnhold, Julia Klosterkötter, Joachim Sachs, Gabriele Lasser, Iris Winklbaur, Bernadette Delespaul, Philippe A Rutten, Bart P. Os, Jim |
| description | Aims
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.
Methods
Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n = 334) and healthy controls (n = 67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At‐Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale.
Results
During follow up, 16.2% of the clinical high‐risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome.
Conclusions
These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder. |
| doi_str_mv | 10.1111/pcn.13555 |
| format | Article |
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Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.
Methods
Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n = 334) and healthy controls (n = 67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At‐Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale.
Results
During follow up, 16.2% of the clinical high‐risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome.
Conclusions
These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1111/pcn.13555</identifier><identifier>PMID: 37070555</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Cannabis ; Cannabis - adverse effects ; clinical high‐risk ; Epidemiology ; Humans ; Incidence ; longitudinal ; Marijuana ; Prospective Studies ; Psychosis ; psychotic disorders ; Psychotic Disorders - diagnosis ; Psychotic Disorders - epidemiology ; Psychotic Disorders - etiology ; Remission ; Risk Factors ; substance use ; THC</subject><ispartof>Psychiatry and clinical neurosciences, 2023-09, Vol.77 (9), p.469-477</ispartof><rights>2023 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2023 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4675-71044de720beb72597e9b1be82b0217e8bbd57c256a0671b15eae6028d5ec9d53</citedby><cites>FETCH-LOGICAL-c4675-71044de720beb72597e9b1be82b0217e8bbd57c256a0671b15eae6028d5ec9d53</cites><orcidid>0000-0002-8920-3407 ; 0000-0001-8969-4595 ; 0000-0002-7813-0281 ; 0000-0002-3525-6415 ; 0000-0003-3056-7262 ; 0000-0002-6022-2364 ; 0000-0003-2851-5252 ; 0000-0002-6263-2332 ; 0000-0002-8671-1238 ; 0000-0002-0543-4516 ; 0000-0001-7987-6619 ; 0000-0002-3820-7926 ; 0000-0002-4715-9890 ; 0000-0002-0868-4449 ; 0000-0003-4895-7023 ; 0000-0001-6099-8464 ; 0000-0001-6361-8789 ; 0000-0003-4381-0532 ; 0000-0003-3541-9947 ; 0000-0002-3789-6168 ; 0000-0003-4233-0182 ; 0000-0002-8359-9877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcn.13555$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcn.13555$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37070555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chester, Lucy A.</creatorcontrib><creatorcontrib>Valmaggia, Lucia R.</creatorcontrib><creatorcontrib>Kempton, Matthew J.</creatorcontrib><creatorcontrib>Chesney, Edward</creatorcontrib><creatorcontrib>Oliver, Dominic</creatorcontrib><creatorcontrib>Hedges, Emily P.</creatorcontrib><creatorcontrib>Klatsa, Elise</creatorcontrib><creatorcontrib>Stahl, Daniel</creatorcontrib><creatorcontrib>Gaag, Mark</creatorcontrib><creatorcontrib>Haan, Lieuwe</creatorcontrib><creatorcontrib>Nelson, Barnaby</creatorcontrib><creatorcontrib>McGorry, Patrick</creatorcontrib><creatorcontrib>Amminger, G. Paul</creatorcontrib><creatorcontrib>Riecher‐Rössler, Anita</creatorcontrib><creatorcontrib>Studerus, Erich</creatorcontrib><creatorcontrib>Bressan, Rodrigo</creatorcontrib><creatorcontrib>Barrantes‐Vidal, Neus</creatorcontrib><creatorcontrib>Krebs, Marie‐Odile</creatorcontrib><creatorcontrib>Glenthøj, Birte</creatorcontrib><creatorcontrib>Nordentoft, Merete</creatorcontrib><creatorcontrib>Ruhrmann, Stephan</creatorcontrib><creatorcontrib>Sachs, Gabriele</creatorcontrib><creatorcontrib>McGuire, Philip</creatorcontrib><creatorcontrib>McGuire, Philip</creatorcontrib><creatorcontrib>Valmaggia, Lucia R.</creatorcontrib><creatorcontrib>Kempton, Matthew J.</creatorcontrib><creatorcontrib>Calem, Maria</creatorcontrib><creatorcontrib>Tognin, Stefania</creatorcontrib><creatorcontrib>Modinos, Gemma</creatorcontrib><creatorcontrib>Haan, Lieuwe</creatorcontrib><creatorcontrib>der Gaag, Mark</creatorcontrib><creatorcontrib>Velthorst, Eva</creatorcontrib><creatorcontrib>Kraan, Tamar C.</creatorcontrib><creatorcontrib>Dam, Daniella S.</creatorcontrib><creatorcontrib>Burger, Nadine</creatorcontrib><creatorcontrib>Nelson, Barnaby</creatorcontrib><creatorcontrib>McGorry, Patrick</creatorcontrib><creatorcontrib>Amminger, G Paul</creatorcontrib><creatorcontrib>Pantelis, Christos</creatorcontrib><creatorcontrib>Politis, Athena</creatorcontrib><creatorcontrib>Goodall, Joanne</creatorcontrib><creatorcontrib>Riecher‐Rössler, Anita</creatorcontrib><creatorcontrib>Borgwardt, Stefan</creatorcontrib><creatorcontrib>Studerus, Erich</creatorcontrib><creatorcontrib>Bressan, Rodrigo</creatorcontrib><creatorcontrib>Gadelha, Ary</creatorcontrib><creatorcontrib>Brietzke, Elisa</creatorcontrib><creatorcontrib>Asevedo, Graccielle</creatorcontrib><creatorcontrib>Asevedo, Elson</creatorcontrib><creatorcontrib>Zugman, Andre</creatorcontrib><creatorcontrib>Barrantes‐Vidal, Neus</creatorcontrib><creatorcontrib>Domínguez‐Martínez, Tecelli</creatorcontrib><creatorcontrib>Racioppi, Anna</creatorcontrib><creatorcontrib>Kwapil, Thomas R.</creatorcontrib><creatorcontrib>Monsonet, Manel</creatorcontrib><creatorcontrib>Hinojosa, Lídia</creatorcontrib><creatorcontrib>Kazes, Mathilde</creatorcontrib><creatorcontrib>Daban, Claire</creatorcontrib><creatorcontrib>Bourgin, Julie</creatorcontrib><creatorcontrib>Gay, Olivier</creatorcontrib><creatorcontrib>Mam‐Lam‐Fook, Célia</creatorcontrib><creatorcontrib>Krebs, Marie‐Odile</creatorcontrib><creatorcontrib>Nordholm, Dorte</creatorcontrib><creatorcontrib>Randers, Lasse</creatorcontrib><creatorcontrib>Krakauer, Kristine</creatorcontrib><creatorcontrib>Glenthøj, Louise</creatorcontrib><creatorcontrib>Glenthøj, Birte</creatorcontrib><creatorcontrib>Nordentoft, Merete</creatorcontrib><creatorcontrib>Ruhrmann, Stephan</creatorcontrib><creatorcontrib>Gebhard, Dominika</creatorcontrib><creatorcontrib>Arnhold, Julia</creatorcontrib><creatorcontrib>Klosterkötter, Joachim</creatorcontrib><creatorcontrib>Sachs, Gabriele</creatorcontrib><creatorcontrib>Lasser, Iris</creatorcontrib><creatorcontrib>Winklbaur, Bernadette</creatorcontrib><creatorcontrib>Delespaul, Philippe A</creatorcontrib><creatorcontrib>Rutten, Bart P.</creatorcontrib><creatorcontrib>Os, Jim</creatorcontrib><creatorcontrib>EU-GEI High Risk Study Group</creatorcontrib><creatorcontrib>for the EU‐GEI High Risk Study Group</creatorcontrib><title>Influence of cannabis use on incidence of psychosis in people at clinical high risk</title><title>Psychiatry and clinical neurosciences</title><addtitle>Psychiatry Clin Neurosci</addtitle><description>Aims
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.
Methods
Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n = 334) and healthy controls (n = 67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At‐Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale.
Results
During follow up, 16.2% of the clinical high‐risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome.
Conclusions
These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder.</description><subject>Cannabis</subject><subject>Cannabis - adverse effects</subject><subject>clinical high‐risk</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>longitudinal</subject><subject>Marijuana</subject><subject>Prospective Studies</subject><subject>Psychosis</subject><subject>psychotic disorders</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Psychotic Disorders - etiology</subject><subject>Remission</subject><subject>Risk Factors</subject><subject>substance use</subject><subject>THC</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctOAyEYhYnReKkufAFD4kYXU4EZhunGxDTekkZN1DUB5m-LUhiHjqZvL1pr1EQWXHK-HA4chPYp6dM0Thrj-zTnnK-hbVoUJKMVHaynfc7yjOa03EI7MT4RQvK8pJtoKxdEkMRvo_trP3YdeAM4jLFR3ittI-5iOntsvbH1SmziwkxDTKr1uIHQOMBqjo2z3hrl8NROpri18XkXbYyVi7D3tfbQ48X5w_AqG91eXg_PRpkpSsEzQUlR1CAY0aAF4wMBA001VEwTRgVUWtdcGMZLRUpBNeWgoCSsqjmYQc3zHjpd-jadnkFtwM9b5WTT2plqFzIoK38r3k7lJLxKUVLOxYfB0ZdBG146iHM5s9GAc8pD6KJkVbqtKqr0bz10-Ad9Cl3r0_MSlUKxNJeJOl5Spg0xtjD-DkOJ_KhKpqrkZ1WJPfiZ_ptcdZOAkyXwZh0s_neSd8ObpeU7YPCddA</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Chester, Lucy A.</creator><creator>Valmaggia, Lucia R.</creator><creator>Kempton, Matthew J.</creator><creator>Chesney, Edward</creator><creator>Oliver, Dominic</creator><creator>Hedges, Emily P.</creator><creator>Klatsa, Elise</creator><creator>Stahl, Daniel</creator><creator>Gaag, Mark</creator><creator>Haan, Lieuwe</creator><creator>Nelson, Barnaby</creator><creator>McGorry, Patrick</creator><creator>Amminger, G. 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Paul ; Riecher‐Rössler, Anita ; Studerus, Erich ; Bressan, Rodrigo ; Barrantes‐Vidal, Neus ; Krebs, Marie‐Odile ; Glenthøj, Birte ; Nordentoft, Merete ; Ruhrmann, Stephan ; Sachs, Gabriele ; McGuire, Philip ; McGuire, Philip ; Valmaggia, Lucia R. ; Kempton, Matthew J. ; Calem, Maria ; Tognin, Stefania ; Modinos, Gemma ; Haan, Lieuwe ; der Gaag, Mark ; Velthorst, Eva ; Kraan, Tamar C. ; Dam, Daniella S. ; Burger, Nadine ; Nelson, Barnaby ; McGorry, Patrick ; Amminger, G Paul ; Pantelis, Christos ; Politis, Athena ; Goodall, Joanne ; Riecher‐Rössler, Anita ; Borgwardt, Stefan ; Studerus, Erich ; Bressan, Rodrigo ; Gadelha, Ary ; Brietzke, Elisa ; Asevedo, Graccielle ; Asevedo, Elson ; Zugman, Andre ; Barrantes‐Vidal, Neus ; Domínguez‐Martínez, Tecelli ; Racioppi, Anna ; Kwapil, Thomas R. ; Monsonet, Manel ; Hinojosa, Lídia ; Kazes, Mathilde ; Daban, Claire ; Bourgin, Julie ; Gay, Olivier ; Mam‐Lam‐Fook, Célia ; Krebs, Marie‐Odile ; Nordholm, Dorte ; Randers, Lasse ; Krakauer, Kristine ; Glenthøj, Louise ; Glenthøj, Birte ; Nordentoft, Merete ; Ruhrmann, Stephan ; Gebhard, Dominika ; Arnhold, Julia ; Klosterkötter, Joachim ; Sachs, Gabriele ; Lasser, Iris ; Winklbaur, Bernadette ; Delespaul, Philippe A ; Rutten, Bart P. ; Os, Jim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4675-71044de720beb72597e9b1be82b0217e8bbd57c256a0671b15eae6028d5ec9d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cannabis</topic><topic>Cannabis - adverse effects</topic><topic>clinical high‐risk</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>longitudinal</topic><topic>Marijuana</topic><topic>Prospective Studies</topic><topic>Psychosis</topic><topic>psychotic disorders</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - epidemiology</topic><topic>Psychotic Disorders - etiology</topic><topic>Remission</topic><topic>Risk Factors</topic><topic>substance use</topic><topic>THC</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chester, Lucy A.</creatorcontrib><creatorcontrib>Valmaggia, Lucia R.</creatorcontrib><creatorcontrib>Kempton, Matthew J.</creatorcontrib><creatorcontrib>Chesney, Edward</creatorcontrib><creatorcontrib>Oliver, Dominic</creatorcontrib><creatorcontrib>Hedges, Emily P.</creatorcontrib><creatorcontrib>Klatsa, Elise</creatorcontrib><creatorcontrib>Stahl, Daniel</creatorcontrib><creatorcontrib>Gaag, Mark</creatorcontrib><creatorcontrib>Haan, Lieuwe</creatorcontrib><creatorcontrib>Nelson, Barnaby</creatorcontrib><creatorcontrib>McGorry, Patrick</creatorcontrib><creatorcontrib>Amminger, G. 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Paul</au><au>Riecher‐Rössler, Anita</au><au>Studerus, Erich</au><au>Bressan, Rodrigo</au><au>Barrantes‐Vidal, Neus</au><au>Krebs, Marie‐Odile</au><au>Glenthøj, Birte</au><au>Nordentoft, Merete</au><au>Ruhrmann, Stephan</au><au>Sachs, Gabriele</au><au>McGuire, Philip</au><au>McGuire, Philip</au><au>Valmaggia, Lucia R.</au><au>Kempton, Matthew J.</au><au>Calem, Maria</au><au>Tognin, Stefania</au><au>Modinos, Gemma</au><au>Haan, Lieuwe</au><au>der Gaag, Mark</au><au>Velthorst, Eva</au><au>Kraan, Tamar C.</au><au>Dam, Daniella S.</au><au>Burger, Nadine</au><au>Nelson, Barnaby</au><au>McGorry, Patrick</au><au>Amminger, G Paul</au><au>Pantelis, Christos</au><au>Politis, Athena</au><au>Goodall, Joanne</au><au>Riecher‐Rössler, Anita</au><au>Borgwardt, Stefan</au><au>Studerus, Erich</au><au>Bressan, Rodrigo</au><au>Gadelha, Ary</au><au>Brietzke, Elisa</au><au>Asevedo, Graccielle</au><au>Asevedo, Elson</au><au>Zugman, Andre</au><au>Barrantes‐Vidal, Neus</au><au>Domínguez‐Martínez, Tecelli</au><au>Racioppi, Anna</au><au>Kwapil, Thomas R.</au><au>Monsonet, Manel</au><au>Hinojosa, Lídia</au><au>Kazes, Mathilde</au><au>Daban, Claire</au><au>Bourgin, Julie</au><au>Gay, Olivier</au><au>Mam‐Lam‐Fook, Célia</au><au>Krebs, Marie‐Odile</au><au>Nordholm, Dorte</au><au>Randers, Lasse</au><au>Krakauer, Kristine</au><au>Glenthøj, Louise</au><au>Glenthøj, Birte</au><au>Nordentoft, Merete</au><au>Ruhrmann, Stephan</au><au>Gebhard, Dominika</au><au>Arnhold, Julia</au><au>Klosterkötter, Joachim</au><au>Sachs, Gabriele</au><au>Lasser, Iris</au><au>Winklbaur, Bernadette</au><au>Delespaul, Philippe A</au><au>Rutten, Bart P.</au><au>Os, Jim</au><aucorp>EU-GEI High Risk Study Group</aucorp><aucorp>for the EU‐GEI High Risk Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of cannabis use on incidence of psychosis in people at clinical high risk</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2023-09</date><risdate>2023</risdate><volume>77</volume><issue>9</issue><spage>469</spage><epage>477</epage><pages>469-477</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>Aims
Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.
Methods
Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n = 334) and healthy controls (n = 67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At‐Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale.
Results
During follow up, 16.2% of the clinical high‐risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome.
Conclusions
These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>37070555</pmid><doi>10.1111/pcn.13555</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8920-3407</orcidid><orcidid>https://orcid.org/0000-0001-8969-4595</orcidid><orcidid>https://orcid.org/0000-0002-7813-0281</orcidid><orcidid>https://orcid.org/0000-0002-3525-6415</orcidid><orcidid>https://orcid.org/0000-0003-3056-7262</orcidid><orcidid>https://orcid.org/0000-0002-6022-2364</orcidid><orcidid>https://orcid.org/0000-0003-2851-5252</orcidid><orcidid>https://orcid.org/0000-0002-6263-2332</orcidid><orcidid>https://orcid.org/0000-0002-8671-1238</orcidid><orcidid>https://orcid.org/0000-0002-0543-4516</orcidid><orcidid>https://orcid.org/0000-0001-7987-6619</orcidid><orcidid>https://orcid.org/0000-0002-3820-7926</orcidid><orcidid>https://orcid.org/0000-0002-4715-9890</orcidid><orcidid>https://orcid.org/0000-0002-0868-4449</orcidid><orcidid>https://orcid.org/0000-0003-4895-7023</orcidid><orcidid>https://orcid.org/0000-0001-6099-8464</orcidid><orcidid>https://orcid.org/0000-0001-6361-8789</orcidid><orcidid>https://orcid.org/0000-0003-4381-0532</orcidid><orcidid>https://orcid.org/0000-0003-3541-9947</orcidid><orcidid>https://orcid.org/0000-0002-3789-6168</orcidid><orcidid>https://orcid.org/0000-0003-4233-0182</orcidid><orcidid>https://orcid.org/0000-0002-8359-9877</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1323-1316 |
| ispartof | Psychiatry and clinical neurosciences, 2023-09, Vol.77 (9), p.469-477 |
| issn | 1323-1316 1440-1819 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7615575 |
| source | MEDLINE; Freely Accessible Japanese Titles; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Cannabis Cannabis - adverse effects clinical high‐risk Epidemiology Humans Incidence longitudinal Marijuana Prospective Studies Psychosis psychotic disorders Psychotic Disorders - diagnosis Psychotic Disorders - epidemiology Psychotic Disorders - etiology Remission Risk Factors substance use THC |
| title | Influence of cannabis use on incidence of psychosis in people at clinical high risk |
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