Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain unclear. We performed a comprehensive immunophenotypic and transcriptome analysis, at a bulk and single-cell level, of neu...

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Veröffentlicht in:	Nature immunology 2022-10, Vol.23 (10), p.1470-1483
Hauptverfasser:	Montaldo, Elisa, Lusito, Eleonora, Bianchessi, Valentina, Caronni, Nicoletta, Scala, Serena, Basso-Ricci, Luca, Cantaffa, Carla, Masserdotti, Alice, Barilaro, Mattia, Barresi, Simona, Genua, Marco, Vittoria, Francesco Maria, Barbiera, Giulia, Lazarevic, Dejan, Messina, Carlo, Xue, Elisabetta, Marktel, Sarah, Tresoldi, Cristina, Milani, Raffaella, Ronchi, Paola, Gattillo, Salvatore, Santoleri, Luca, Di Micco, Raffaella, Ditadi, Andrea, Belfiori, Giulio, Aleotti, Francesca, Naldini, Matteo Maria, Gentner, Bernhard, Gardiman, Elisa, Tamassia, Nicola, Cassatella, Marco Antonio, Hidalgo, Andrés, Kwok, Immanuel, Ng, Lai Guan, Crippa, Stefano, Falconi, Massimo, Pettinella, Francesca, Scapini, Patrizia, Naldini, Luigi, Ciceri, Fabio, Aiuti, Alessandro, Ostuni, Renato
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2502 631/250/2504/223/1699 Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Cell differentiation Growth factors Hematopoietic stem cells Heterogeneity Humans Immunology Infectious Diseases Integrated control Interferon Interferons - genetics Interferons - metabolism Leukocytes (neutrophilic) Monocytes Myelopoiesis Neutrophils Neutrophils - metabolism Pancreatic cancer Pancreatic islet transplantation Plastics - metabolism Resource Stem cells Transcriptomes
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