Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS

The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of >25,000 variants in untranslated regions of 6,139 amyotrophic lateral sclerosis (ALS) wh...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2022-04, Vol.25 (4), p.433-445
Hauptverfasser:	Eitan, Chen, Siany, Aviad, Barkan, Elad, Olender, Tsviya, van Eijk, Kristel R., Moisse, Matthieu, Farhan, Sali M. K., Danino, Yehuda M., Yanowski, Eran, Marmor-Kollet, Hagai, Rivkin, Natalia, Yacovzada, Nancy Sarah, Hung, Shu-Ting, Cooper-Knock, Johnathan, Yu, Chien-Hsiung, Louis, Cynthia, Masters, Seth L., Kenna, Kevin P., van der Spek, Rick A. A., Sproviero, William, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Jones, Ashley R., Elbaz-Alon, Yael, Cohen, Yahel, Chapnik, Elik, Rothschild, Daphna, Weissbrod, Omer, Beck, Gilad, Ainbinder, Elena, Ben-Dor, Shifra, Werneburg, Sebastian, Schafer, Dorothy P., Brown, Robert H., Shaw, Pamela J., Van Damme, Philip, van den Berg, Leonard H., Phatnani, Hemali, Segal, Eran, Ichida, Justin K., Al-Chalabi, Ammar, Veldink, Jan H., Hornstein, Eran
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/21 13/31 3' Untranslated regions 45/43 45/91 631/208/205/2138 631/250/371 631/378/1689/1285 631/378/2583 692/699/375/1917/1285 82/58 96/44 Amyotrophic lateral sclerosis Animal Genetics and Genomics Association analysis Behavioral Sciences Binding Biological Techniques Biomedical and Life Sciences Biomedicine Cytokines Double-stranded RNA Gene sequencing Genetic diversity Genetic variance Genomes Inflammation Interleukin 1 Interleukin 18 Interleukin 18 receptors Microglia Motor neurons mRNA stability Neurobiology Neurosciences Neurotoxicity NF-κB protein Non-coding RNA Pluripotency Proteins Receptors Risk management Signaling Stem cells Whole genome sequencing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!