Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial

Vancomycin is the most widely used antibiotic for neonatal Gram-positive sepsis, but clinical outcome data of dosing strategies are scarce. The NeoVanc programme comprised extensive preclinical studies to inform a randomised controlled trial to assess optimised vancomycin dosing. We compared the eff...

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Veröffentlicht in:	The lancet child & adolescent health 2022-01, Vol.6 (1), p.49-59
Hauptverfasser:	Hill, Louise F, Clements, Michelle N, Turner, Mark A, Donà, Daniele, Lutsar, Irja, Jacqz-Aigrain, Evelyne, Heath, Paul T, Roilides, Emmanuel, Rawcliffe, Louise, Alonso-Diaz, Clara, Baraldi, Eugenio, Dotta, Andrea, Ilmoja, Mari-Liis, Mahaveer, Ajit, Metsvaht, Tuuli, Mitsiakos, George, Papaevangelou, Vassiliki, Sarafidis, Kosmas, Walker, A Sarah, Sharland, Michael, Clements, Michelle, Bafadal, Basma, Alarcon Allen, Ana, Anatolitou, Fani, Del Vecchio, Antonio, Giuffrè, Mario, Karachristou, Korina, Manzoni, Paolo, Martinelli, Stefano, Moriarty, Paul, Nika, Angeliki, Papaevangelou, Vana, Roehr, Charles, Sanchez Alcobendas, Laura, Siahanidou, Tania, Tzialla, Chryssoula, Bonadies, Luca, Booth, Nicola, Catalina Morales-Betancourt, Paola, Cordeiro, Malaika, de Alba Romero, Concha, de la Cruz, Javier, De Luca, Maia, Farina, Daniele, Franco, Caterina, Gialamprinou, Dimitra, Hallik, Maarja, Ilardi, Laura, Insinga, Vincenzo, Iosifidis, Elias, Kalamees, Riste, Kontou, Angeliki, Molnar, Zoltan, Nikaina, Eirini, Petropoulou, Chryssoula, Reyné, Mar, Tataropoulou, Kassandra, Triantafyllidou, Pinelopi, Vontzalidis, Adamantios, Sharland, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Equivalence Trials as Topic Europe Humans Infant Infant, Newborn Infusions, Intravenous Intensive Care Units, Neonatal Sepsis - drug therapy Sepsis - mortality Spain Time Factors Treatment Outcome United Kingdom Vancomycin - administration & dosage Vancomycin - adverse effects
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