Developing novel antifungals: lessons from G protein-coupled receptors

Integral membrane proteins found in the plasma membrane of fungi have great potential for the development of novel antifungal agents.In-depth studies on fungal signaling pathways define proteins that when deleted result in decreased virulence or viability, highlighting their potential as drug target...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2023-03, Vol.44 (3), p.162-174
Hauptverfasser:	Velazhahan, Vaithish, McCann, Bethany L., Bignell, Elaine, Tate, Christopher G.
Format:	Artikel
Sprache:	eng
Schlagworte:	antifungal Antifungal Agents - chemistry Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Aspergillus Candida cryo-EM Humans Mycoses - drug therapy plasma membrane receptors Receptors, G-Protein-Coupled - metabolism structure
Online-Zugang:	Volltext
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