Abnormal folate metabolism in foetuses affected by neural tube defects

Folic acid supplementation can prevent many cases of neural tube defects (NTDs), whereas suboptimal maternal folate status is a risk factor, suggesting that folate metabolism is a key determinant of susceptibility to NTDs. Despite extensive genetic analysis of folate cycle enzymes, and quantificatio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2007-04, Vol.130 (4), p.1043-1049
Hauptverfasser:	Dunlevy, Louisa P. E., Chitty, Lyn S., Burren, Katie A., Doudney, Kit, Stojilkovic-Mikic, Taita, Stanier, Philip, Scott, Rosemary, Copp, Andrew J., Greene, Nicholas D. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anencephaly - embryology Anencephaly - metabolism Animals Antimetabolites - pharmacology Biological and medical sciences Deoxyuridine - pharmacology Development. Senescence. Regeneration. Transplantation Female Ferredoxin-NADP Reductase - genetics Fetal Diseases - metabolism Fetus - drug effects Fetus - metabolism Fibroblasts - metabolism Folic Acid - genetics Folic Acid - metabolism Fundamental and applied biological sciences. Psychology Genotype Humans Medical sciences Methylation Mice Neural Tube Defects - embryology Neural Tube Defects - genetics Neural Tube Defects - metabolism Neurology Neurosurgery NIH 3T3 Cells Polymorphism, Genetic - genetics Pregnancy S-Adenosylhomocysteine - analysis S-Adenosylmethionine - analysis Skull, brain, vascular surgery Spinal Dysraphism - embryology Spinal Dysraphism - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!