3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine (3DA), an S-adenosyl homocysteinase (AHCY) inhibitor, alleviates replicative and on...

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Veröffentlicht in:	Nature aging 2022-09, Vol.2 (9), p.851-866
Hauptverfasser:	Guerrero, Ana, Innes, Andrew J, Roux, Pierre-François, Buisman, Sonja C, Jung, Johannes, Ortet, Laura, Moiseeva, Victoria, Wagner, Verena, Robinson, Lucas, Ausema, Albertina, Potapova, Anna, Perdiguero, Eusebio, Weersing, Ellen, Aarts, Marieke, Martin, Nadine, Wuestefeld, Torsten, Muñoz-Cánoves, Pura, de Haan, Gerald, Bischof, Oliver, Gil, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell cycle Cellular Biology Cellular Senescence - genetics Epigenesis, Genetic Histones - genetics Humans Life Sciences Mice Senescence Stem cells Tubercidin - pharmacology
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