KIR2DS2 expression identifies NK cells with enhanced anti-cancer activity

Natural killer (NK) cells are promising cellular therapeutics against haematological and solid malignancies. Immunogenetic studies have identified that various activating killer cell immunoglobulin-like receptors (KIR) are associated with cancer outcomes. Specifically, KIR2DS2 has been associated wi...

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Veröffentlicht in:The Journal of immunology (1950) 2022-06, Vol.209 (2), p.379-390
Hauptverfasser: Blunt, Matthew D., Pulido, Andres Vallejo, Fisher, Jack G., Graham, Lara V., Doyle, Amber DP, Fulton, Rebecca, Carter, Matthew J., Polak, Marta, Johnson, Peter WM, Cragg, Mark S., Forconi, Francesco, Khakoo, Salim I.
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Sprache:eng
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