Neuropilin-1 is a host factor for SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for host cell attachment and entry. The host protease furin cleaves the full-length precursor S glycoprotein into two associated polypeptides: S1...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-11, Vol.370 (6518), p.861-865
Hauptverfasser:	Daly, James L, Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K, Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F, Horvath, Peter, Sessions, Richard B, Helenius, Ari, Hiscox, Julian A, Teesalu, Tambet, Matthews, David A, Davidson, Andrew D, Collins, Brett M, Cullen, Peter J, Yamauchi, Yohei
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Amino Acid Motifs Angiotensin Angiotensin-Converting Enzyme 2 Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Betacoronavirus - physiology Caco-2 Cells Cell adhesion Cell culture Cell surface Cleavage Coronaviridae Coronavirus Infections - virology Coronaviruses COVID-19 Crystallography Crystallography, X-Ray Disease transmission Epithelial cells Epithelium Furin Furin - metabolism Glycoproteins HeLa Cells Humans Infections Infectivity Literary Devices Monoclonal antibodies Mutagenesis, Site-Directed Neuropilin Neuropilin-1 - antagonists & inhibitors Neuropilin-1 - chemistry Neuropilin-1 - genetics Neuropilin-1 - metabolism Olfactory epithelium Pandemics Peptide Fragments - chemistry Peptide Fragments - metabolism Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - virology Polypeptides Protease Protein Binding Protein Interaction Domains and Motifs Proteinase Proteins Receptors Respiratory diseases RNA Interference RNA-mediated interference SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism Spike protein Substrates Tropism Viral diseases Viral infections Virus Internalization Viruses X-ray crystallography
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