Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

Multiple myeloma (MM) is a neoplastic plasma-cell disorder characterized by clonal proliferation of malignant plasma cells. Despite extensive research, disease heterogeneity within and between treatment-resistant patients is poorly characterized. In the present study, we conduct a prospective, multi...

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Veröffentlicht in:	Nature medicine 2021-03, Vol.27 (3), p.491-503
Hauptverfasser:	Cohen, Yael C., Zada, Mor, Wang, Shuang-Yin, Bornstein, Chamutal, David, Eyal, Moshe, Adi, Li, Baoguo, Shlomi-Loubaton, Shir, Gatt, Moshe E., Gur, Chamutal, Lavi, Noa, Ganzel, Chezi, Luttwak, Efrat, Chubar, Evgeni, Rouvio, Ory, Vaxman, Iuliana, Pasvolsky, Oren, Ballan, Mouna, Tadmor, Tamar, Nemets, Anatoly, Jarchowcky-Dolberg, Osnat, Shvetz, Olga, Laiba, Meirav, Shpilberg, Ofer, Dally, Najib, Avivi, Irit, Weiner, Assaf, Amit, Ido
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/67 Adult Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomedical and Life Sciences Biomedicine Bortezomib Cancer Cancer Research Case-Control Studies Cell proliferation Clinical trials CRISPR Dexamethasone Dexamethasone - administration & dosage Drug resistance Drug Resistance, Neoplasm Drug therapy Female Folding Gene sequencing Health services Heterogeneity Humans Hypoxia Infectious Diseases Lenalidomide - administration & dosage Male Metabolic Diseases Middle Aged Mitochondria Molecular dynamics Molecular Medicine Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - pathology Neoplasm Recurrence, Local Neurosciences Oligopeptides - administration & dosage Oncology, Experimental Patient outcomes Patients Peptidylprolyl isomerase Plasma cells Proteasome inhibitors Protein folding Proteins Relapse Safety Single-Cell Analysis - methods Survival Target recognition Therapeutic applications Therapeutic targets Treatment Outcome Tumor cells Tumors
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