Genome-Protective Topoisomerase 2a-Dependent G2 Arrest Requires p53 in hTERT-Positive Cancer Cells

Topoisomerase 2a (Topo2a)-dependent G2 arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is dysfunctional, a PKCε-dependent failsafe pathway can be triggered. Here we elaborate on recent advances in understanding the underlying mechanisms a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2022-05, Vol.82 (9), p.1762-1773
Hauptverfasser:	Lockwood, Nicola, Martini, Silvia, Lopez-Pardo, Ainara, Deiss, Katharina, Segeren, Hendrika A, Semple, Robert K, Collins, Ian, Repana, Dimitra, Cobbaut, Mathias, Soliman, Tanya, Ciccarelli, Francesca, Parker, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor DNA Damage DNA Topoisomerases, Type II - metabolism Humans Mice Neoplasms - genetics Poly-ADP-Ribose Binding Proteins - metabolism S Phase Signal Transduction - genetics Tumor Suppressor Protein p53 - metabolism
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