Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Locoregional failure (LRF) in patients with breast cancer post-surgery and post-irradiation is linked to a dismal prognosis. In a refined new model, we identified ectonucleotide pyrophosphatase/phosphodiesterase 1/CD203a (ENPP1) to be closely associated with LRF. ENPP1hi circulating tumor cells (CTC...

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Veröffentlicht in:	Cancer discovery 2022-05, Vol.12 (5), p.1356-1377
Hauptverfasser:	Ruiz-Fernández de Córdoba, Borja, Moreno, Haritz, Valencia, Karmele, Perurena, Naiara, Ruedas, Pablo, Walle, Thomas, Pezonaga-Torres, Alberto, Hinojosa, Juan, Guruceaga, Elisabet, Pineda-Lucena, Antonio, Abengózar-Muela, Marta, Cochonneau, Denis, Zandueta, Carolina, Martínez-Canarias, Susana, Teijeira, Álvaro, Ajona, Daniel, Ortiz-Espinosa, Sergio, Morales, Xabier, Ortiz de Solórzano, Carlos, Santisteban, Marta, Ramos-García, Luis I, Guembe, Laura, Strnad, Vratislav, Heymann, Dominique, Hervás-Stubbs, Sandra, Pío, Rubén, Rodríguez-Ruiz, María E, de Andrea, Carlos E, Vicent, Silvestre, Melero, Ignacio, Lecanda, Fernando, Martínez-Monge, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - radiotherapy Cancer Cell Behavior Cellular Biology Endocrinology and metabolism Female Haptoglobins Human health and pathology Humans Life Sciences Myeloid-Derived Suppressor Cells - metabolism Neoplasm Recurrence, Local - genetics Pediatrics Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Pyrophosphatases - genetics Pyrophosphatases - metabolism Rhumatology and musculoskeletal system Tissues and Organs
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