Single-cell analysis of structural variations and complex rearrangements with tri-channel processing

Structural variation (SV), involving deletions, duplications, inversions and translocations of DNA segments, is a major source of genetic variability in somatic cells and can dysregulate cancer-related pathways. However, discovering somatic SVs in single cells has been challenging, with copy-number-...

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Veröffentlicht in:	Nature biotechnology 2020-03, Vol.38 (3), p.343-354
Hauptverfasser:	Sanders, Ashley D., Meiers, Sascha, Ghareghani, Maryam, Porubsky, David, Jeong, Hyobin, van Vliet, M. Alexandra C. C., Rausch, Tobias, Richter-Pechańska, Paulina, Kunz, Joachim B., Jenni, Silvia, Bolognini, Davide, Longo, Gabriel M. C., Raeder, Benjamin, Kinanen, Venla, Zimmermann, Jürgen, Benes, Vladimir, Schrappe, Martin, Mardin, Balca R., Kulozik, Andreas E., Bornhauser, Beat, Bourquin, Jean-Pierre, Marschall, Tobias, Korbel, Jan O.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/208/212 631/67/2329 631/67/69 Agriculture Bioinformatics Biological evolution Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cancer Cell fusion Cell Line Chromothripsis Clonal Evolution Computational Biology - methods Computer applications Cytogenetics Deoxyribonucleic acid Development and progression DNA Epithelial cells Gene Rearrangement Genetic aspects Genetic variability Genetic variation Genomic Structural Variation Haplotypes Health aspects Humans INDEL Mutation Inversions Leukemia Leukemia - genetics Life Sciences Mosaicism Mutation (Biology) Physiological aspects Precision medicine Sequence Inversion Single-Cell Analysis - methods Somatic cells Structure Translocation Translocation, Genetic
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