Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

FAT1 , which encodes a protocadherin, is one of the most frequently mutated genes in human cancers 1 – 5 . However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. Here, using mouse models of skin squamous cell carcinoma...

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Veröffentlicht in:	Nature (London) 2021-01, Vol.589 (7842), p.448-455
Hauptverfasser:	Pastushenko, Ievgenia, Mauri, Federico, Song, Yura, de Cock, Florian, Meeusen, Bob, Swedlund, Benjamin, Impens, Francis, Van Haver, Delphi, Opitz, Matthieu, Thery, Manuel, Bareche, Yacine, Lapouge, Gaelle, Vermeersch, Marjorie, Van Eycke, Yves-Rémi, Balsat, Cédric, Decaestecker, Christine, Sokolow, Youri, Hassid, Sergio, Perez-Bustillo, Alicia, Agreda-Moreno, Beatriz, Rios-Buceta, Luis, Jaen, Pedro, Redondo, Pedro, Sieira-Gil, Ramon, Millan-Cayetano, Jose F., Sanmatrtin, Onofre, D’Haene, Nicky, Moers, Virginie, Rozzi, Milena, Blondeau, Jeremy, Lemaire, Sophie, Scozzaro, Samuel, Janssens, Veerle, De Troya, Magdalena, Dubois, Christine, Pérez-Morga, David, Salmon, Isabelle, Sotiriou, Christos, Helmbacher, Francoise, Blanpain, Cédric
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/106 13/31 13/51 13/95 14/28 14/63 38/22 38/23 45/15 45/23 45/41 45/77 45/90 45/91 631/67/2329 631/67/71 64/60 82/58 82/80 Adaptor Proteins, Signal Transducing - metabolism Animal models Animals Biological transport Cadherins Cadherins - deficiency Cadherins - genetics Cadherins - metabolism Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology CD44 antigen Cell adhesion & migration Cell culture Chromatin Chromosome deletion Deletion Development and progression Diagnosis Disease Progression Drug resistance Enhancer of Zeste Homolog 2 Protein - metabolism Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Gene Deletion Gene Expression Regulation, Neoplastic Genotype & phenotype Histology Humanities and Social Sciences Humans Hyaluronan Receptors - metabolism Invasiveness Life Sciences Lung cancer Lung carcinoma Lung Neoplasms - genetics Lung Neoplasms - pathology Mesenchyme Mesoderm - metabolism Mesoderm - pathology Metastases Metastasis Mice Molecular modelling multidisciplinary Mutation Neoplasm Metastasis - drug therapy Neoplasm Metastasis - genetics Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nuclear transport Observations Phenotype Phenotypes Phosphoproteins - analysis Phosphoproteins - metabolism Physiological aspects Proteomics Protocadherin Science Science (multidisciplinary) Signal Transduction Skin cancer Skin Neoplasms - genetics Skin Neoplasms - pathology SOXB1 Transcription Factors - metabolism Squamous cell carcinoma Squamous cell tumors src-Family Kinases - metabolism Transcription Transcription Factors - metabolism Translocation Tumorigenesis Tumors YAP-Signaling Proteins Yes-associated protein Zinc Finger E-box-Binding Homeobox 1 - metabolism
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