Latest Advances in Imaging Oxidative Stress in Cancer
Oxidative stress is the imbalance of harmful reactive oxygen species (ROS) and the action of neutralizing antioxidant mechanisms. If left unchecked, the deleterious effects of oxidative stress result in damage to DNA, proteins, and membranes, ultimately leading to cell death. Tumors are highly proli...
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| Veröffentlicht in: | Journal of Nuclear Medicine 2021-11, Vol.62 (11), p.1506-1510 |
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| container_title | Journal of Nuclear Medicine |
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| creator | Greenwood, Hannah E Witney, Timothy H |
| description | Oxidative stress is the imbalance of harmful reactive oxygen species (ROS) and the action of neutralizing antioxidant mechanisms. If left unchecked, the deleterious effects of oxidative stress result in damage to DNA, proteins, and membranes, ultimately leading to cell death. Tumors are highly proliferative and consequently generate high levels of mitochondrial ROS. To compensate for this and maintain redox homeostasis, cancer cells upregulate protective antioxidant pathways, which are further amplified in drug-resistant tumors. This review provides an overview of the latest molecular imaging techniques designed to image oxidative stress in cancer. New probes can now assess heterogeneous ROS and antioxidant production within tumors and across lesions. Together, the noninvasive imaging of these dynamic processes holds great promise for monitoring response to treatment and predicting drug resistance and may provide insight into the metastatic potential of tumors. |
| doi_str_mv | 10.2967/jnumed.120.256974 |
| format | Article |
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Together, the noninvasive imaging of these dynamic processes holds great promise for monitoring response to treatment and predicting drug resistance and may provide insight into the metastatic potential of tumors.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Cancer</subject><subject>Cell death</subject><subject>DNA damage</subject><subject>DNA probes</subject><subject>Drug resistance</subject><subject>Focus on Molecular Imaging</subject><subject>Glutathione</subject><subject>Homeostasis</subject><subject>Imaging techniques</subject><subject>Magnetic Resonance Imaging</subject><subject>Metastases</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Mitochondria</subject><subject>Molecular Imaging</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Oxidative Stress</subject><subject>Positron-Emission Tomography</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Tumors</subject><issn>0161-5505</issn><issn>1535-5667</issn><issn>1535-5667</issn><issn>2159-662X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1LwzAUhoMobk5_gDdS8MabzqZpvm6EMfwYDHahXofTNJ0ZXTuTdui_N7NzqFfhcJ7zkpcHoUucjFPJ-O2q7tamGOM0zJRJnh2hIaaExpQxfoyGCWY4pjShA3Tm_SpJEiaEOEUDkhFKBMdDROfQGt9Gk2ILtTY-snU0W8PS1sto8WELaO3WRM-tM_57N91R7hydlFB5c7F_R-j14f5l-hTPF4-z6WQea5KlWUwLykSRM8ElaOCgcZ5nvJSUCwKMU8yFASigzNIcpC4TKDHjWBdSaiZFQUbors_ddHloqk3dOqjUxtk1uE_VgFV_N7V9U8tmqzjDWBIRAm72Aa5570JRtbZem6qC2jSdVymlMiM4ZTyg1__QVdO5OtQLlCQhLiUsULintGu8d6Y8fAYnaidF9VJUkKJ6KeHm6neLw8WPBfIFjeaJSA</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Greenwood, Hannah E</creator><creator>Witney, Timothy H</creator><general>Society of Nuclear Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202111</creationdate><title>Latest Advances in Imaging Oxidative Stress in Cancer</title><author>Greenwood, Hannah E ; 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If left unchecked, the deleterious effects of oxidative stress result in damage to DNA, proteins, and membranes, ultimately leading to cell death. Tumors are highly proliferative and consequently generate high levels of mitochondrial ROS. To compensate for this and maintain redox homeostasis, cancer cells upregulate protective antioxidant pathways, which are further amplified in drug-resistant tumors. This review provides an overview of the latest molecular imaging techniques designed to image oxidative stress in cancer. New probes can now assess heterogeneous ROS and antioxidant production within tumors and across lesions. 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| subjects | Animals Antioxidants Cancer Cell death DNA damage DNA probes Drug resistance Focus on Molecular Imaging Glutathione Homeostasis Imaging techniques Magnetic Resonance Imaging Metastases Mice Mice, Transgenic Mitochondria Molecular Imaging Neoplasms - diagnostic imaging Oxidative Stress Positron-Emission Tomography Reactive oxygen species Reactive Oxygen Species - metabolism Tumors |
| title | Latest Advances in Imaging Oxidative Stress in Cancer |
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