Structure-based classification of tauopathies

The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the structures of tau filaments from Alzheimer’s disease 1 , 2 , Pick’s disease 3 , chronic traumatic ence...

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Veröffentlicht in:	Nature (London) 2021-10, Vol.598 (7880), p.359-363
Hauptverfasser:	Shi, Yang, Zhang, Wenjuan, Yang, Yang, Murzin, Alexey G., Falcon, Benjamin, Kotecha, Abhay, van Beers, Mike, Tarutani, Airi, Kametani, Fuyuki, Garringer, Holly J., Vidal, Ruben, Hallinan, Grace I., Lashley, Tammaryn, Saito, Yuko, Murayama, Shigeo, Yoshida, Mari, Tanaka, Hidetomo, Kakita, Akiyoshi, Ikeuchi, Takeshi, Robinson, Andrew C., Mann, David M. A., Kovacs, Gabor G., Revesz, Tamas, Ghetti, Bernardino, Hasegawa, Masato, Goedert, Michel, Scheres, Sjors H. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 13/1 13/51 45/47 631/378/1689/364 631/535/1258/1259 82/29 Aged Aged, 80 and over Aging Alzheimer's disease Amino Acid Sequence Brain Chronic traumatic encephalopathy Classification Cryoelectron Microscopy Degeneration Dementia Dementia - genetics Dementia disorders Denmark Electron microscopy Female Filaments Health aspects Humanities and Social Sciences Humans Introns - genetics Male Microscopy Microtubules Middle Aged Models, Molecular multidisciplinary Mutation Nervous system Neurodegeneration Neurodegenerative diseases Paralysis Physiological aspects Progressive supranuclear palsy Protein Folding Protein Isoforms - chemistry Protein Isoforms - ultrastructure Proteins Science Science (multidisciplinary) Structure Supranuclear Palsy, Progressive Symmetry Tau protein Tau proteins tau Proteins - chemistry tau Proteins - ultrastructure Tauopathies - classification Tauopathies - pathology United Kingdom
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