Gating and modulation of a hetero-octameric AMPA glutamate receptor

AMPA receptors (AMPARs) mediate the majority of excitatory transmission in the brain and enable the synaptic plasticity that underlies learning 1 . A diverse array of AMPAR signalling complexes are established by receptor auxiliary subunits, which associate with the AMPAR in various combinations to...

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Veröffentlicht in:	Nature (London) 2021-06, Vol.594 (7863), p.454-458
Hauptverfasser:	Zhang, Danyang, Watson, Jake F., Matthews, Peter M., Cais, Ondrej, Greger, Ingo H.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/378/2586 631/535/1258/1259 9/74 Amino Acid Sequence AMPA receptors Animals Asymmetry Binding sites Brain Calcium Channels - chemistry Calcium Channels - metabolism Calcium Channels - ultrastructure Cellular signal transduction Channel gating Conformation Cryoelectron Microscopy Electron microscopy Endoplasmic reticulum Forebrain Glutamate receptors Hippocampus Humanities and Social Sciences Ion Channel Gating Ligands Lipid Metabolism Lipid rafts Lipids Mice Mice, Inbred C57BL Microscopy Models, Molecular multidisciplinary Neurological research Neuroplasticity Observations Physiological aspects Protein Multimerization Protein Subunits - chemistry Protein Subunits - metabolism Proteins Pyramidal cells Pyramidal Cells - metabolism Receptors Receptors, AMPA - chemistry Receptors, AMPA - metabolism Receptors, AMPA - ultrastructure Rotation Science Science (multidisciplinary) Synaptic plasticity α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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