Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells

Pathogens and vaccines that produce persisting antigens can generate expanded pools of effector memory CD8 + T cells, described as memory inflation. While properties of inflating memory CD8 + T cells have been characterized, the specific cell types and tissue factors responsible for their maintenanc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2021-08, Vol.22 (8), p.1042-1051
Hauptverfasser:	Cupovic, Jovana, Ring, Sandra S., Onder, Lucas, Colston, Julia M., Lütge, Mechthild, Cheng, Hung-Wei, De Martin, Angelina, Provine, Nicholas M., Flatz, Lukas, Oxenius, Annette, Scandella, Elke, Krebs, Philippe, Engeler, Daniel, Klenerman, Paul, Ludewig, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127/1213 631/250/1619/554/1834 631/250/590 Adenoviridae - genetics Adenoviridae - immunology Adenoviruses Animals Antigen presentation Antigens Biomedical and Life Sciences Biomedicine CCL19 protein CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Cell Line, Tumor Chemokine CCL19 - metabolism Chimera - genetics Cytokines Effector cells Epitopes, T-Lymphocyte - immunology Expression vectors Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Genetic Vectors - immunology Humans Immunization Immunologic Memory - immunology Immunological memory Immunology Infectious Diseases Interleukin-33 - immunology Lung - cytology Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Melanoma, Experimental - immunology Memory cells Mice Mice, Inbred C57BL Mice, Knockout Myeloid cells Stromal cells Stromal Cells - immunology Vaccination Vaccines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!