Discovery of small molecules that induce lysosomal cell death in cancer cells using a phenotypic screening platform

The lysosomal cell death, (LCD), pathway is a caspase-independent, cell death pathway that has been suggested as a possible target for cancer therapy; making the development of sensitive and specific high-throughput (HT) assays to identify LCD-inducers highly desirable. Here, we report a two-step HT...

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Veröffentlicht in:	Assay and drug development technologies 2016-09, Vol.14 (8), p.489-510
Hauptverfasser:	Pagliero, Romina J., D'Astolfo, Diego S., Lelieveld, Daphne, Pratiwi, Riyona D., Aits, Sonja, Jaattela, Marja, Martin, Nathaniel, Liskamp, Robert, Klumperman, Judith, Egan, David A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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