Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors

Lung cancers driven by mutant forms of EGFR invariably develop resistance to kinase inhibitors, often due to secondary mutations. Here we describe an unconventional mechanism of resistance to dacomitinib, a newly approved covalent EGFR kinase inhibitor, and uncover a previously unknown step of resis...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-07, Vol.81 (14), p.3862-3875
Hauptverfasser:	Haga, Yuya, Marrocco, Ilaria, Noronha, Ashish, Uribe, Mary Luz, Nataraj, Nishanth Belugali, Sekar, Arunachalam, Drago-Garcia, Diana, Borgoni, Simone, Lindzen, Moshit, Giri, Suvendu, Wiemann, Stefan, Tsutsumi, Yasuo, Yarden, Yosef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Humans Mice Mice, Nude Phenotype Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use
Online-Zugang:	Volltext
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