NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have many tumor-promoting functions and promote immune evasion through multiple mechanisms, but as yet, no CAF-specific inhibitors ar...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2020-05, Vol.80 (9), p.1846-1860
Hauptverfasser:	Ford, Kirsty, Hanley, Christopher J, Mellone, Massimiliano, Szyndralewiez, Cedric, Heitz, Freddy, Wiesel, Philippe, Wood, Oliver, Machado, Maria, Lopez, Maria-Antoinette, Ganesan, Anusha-Preethi, Wang, Chuan, Chakravarthy, Ankur, Fenton, Tim R, King, Emma V, Vijayanand, Pandurangan, Ottensmeier, Christian H, Al-Shamkhani, Aymen, Savelyeva, Natalia, Thomas, Gareth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer-Associated Fibroblasts CD8-Positive T-Lymphocytes Cell Line, Tumor Humans Immunotherapy Mice NADPH Oxidase 4 Neoplasms Reactive Oxygen Species
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