Stepwise pathogenic evolution of Mycobacterium abscessus

Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as , have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of the environmental organism through the global cystic fibrosis population, we have defined key, gene...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-04, Vol.372 (6541)
Hauptverfasser:	Bryant, Josephine M, Brown, Karen P, Burbaud, Sophie, Everall, Isobel, Belardinelli, Juan M, Rodriguez-Rincon, Daniela, Grogono, Dorothy M, Peterson, Chelsea M, Verma, Deepshikha, Evans, Ieuan E, Ruis, Christopher, Weimann, Aaron, Arora, Divya, Malhotra, Sony, Bannerman, Bridget, Passemar, Charlotte, Templeton, Kerra, MacGregor, Gordon, Jiwa, Kasim, Fisher, Andrew J, Blundell, Tom L, Ordway, Diane J, Jackson, Mary, Parkhill, Julian, Floto, R Andres
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Bronchopulmonary infection Chronic infection Cloning Communicable Diseases, Emerging - microbiology Communicable Diseases, Emerging - transmission Contamination Cross-infection Cystic fibrosis Datasets as Topic Disease control Epigenesis, Genetic Epigenetics Evolution Evolution, Molecular Evolutionary genetics Fitness Fomites Gene transfer Gene Transfer, Horizontal Genes Genetic Fitness Genome, Bacterial Genomic analysis Horizontal transfer Humans Infections Infectivity Inflammation Introduced species Lung - microbiology Lungs Macrophages Multidrug resistance Mutation Mycobacterium abscessus Mycobacterium abscessus - genetics Mycobacterium abscessus - pathogenicity Mycobacterium Infections, Nontuberculous - microbiology Mycobacterium Infections, Nontuberculous - transmission Mycobacterium tuberculosis Pathogenicity Pathogens Patients Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - transmission Population density Regulators Reproductive fitness Saprophytes Species Survival Transcription Tuberculosis Virulence Virulence - genetics
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