A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

The ability of gut bacterial pathogens to escape immunity by antigenic variation—particularly via changes to surface-exposed antigens—is a major barrier to immune clearance 1 . However, not all variants are equally fit in all environments 2 , 3 . It should therefore be possible to exploit such immun...

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Veröffentlicht in:	Nature microbiology 2021-07, Vol.6 (7), p.830-841
Hauptverfasser:	Diard, Médéric, Bakkeren, Erik, Lentsch, Verena, Rocker, Andrea, Bekele, Nahimi Amare, Hoces, Daniel, Aslani, Selma, Arnoldini, Markus, Böhi, Flurina, Schumann-Moor, Kathrin, Adamcik, Jozef, Piccoli, Luca, Lanzavecchia, Antonio, Stadtmueller, Beth M., Donohue, Nicholas, van der Woude, Marjan W., Hockenberry, Alyson, Viollier, Patrick H., Falquet, Laurent, Wüthrich, Daniel, Bonfiglio, Ferdinando, Loverdo, Claude, Egli, Adrian, Zandomeneghi, Giorgia, Mezzenga, Raffaele, Holst, Otto, Meier, Beat H., Hardt, Wolf-Dietrich, Slack, Emma
Format:	Artikel
Sprache:	eng
Schlagworte:	101/6 13/1 13/31 42/41 45/23 45/29 45/77 631/181/2475 631/250/347 631/326/41/2531 631/326/421 64/60 Administration, Oral Animals Antibodies, Bacterial - immunology Antigenic Variation Antigens Bacterial Proteins - genetics Bacteriology Biomedical and Life Sciences Colonization Detergents Digestive system Evolution Evolution, Molecular Gastrointestinal tract Genetic Fitness Hexosyltransferases - genetics Human health and pathology Immune Evasion Immunity, Mucosal Immunoglobulin A Immunoglobulin A - immunology Immunoglobulins Immunology Infectious Diseases Intestine Intestines - immunology Intestines - microbiology Letter Life Sciences Medical Microbiology Mice Microbiology Microbiology and Parasitology Mucosa Mutants Mutation O Antigens - genetics O Antigens - immunology Parasitology Phages Predation Salmonella Salmonella Infections - microbiology Salmonella Infections - prevention & control Salmonella typhimurium - genetics Salmonella typhimurium - immunology Salmonella typhimurium - pathogenicity Salmonella Vaccines - administration & dosage Salmonella Vaccines - immunology Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Vaccinology Virology Virulence
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