Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties

The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that the transcription factor Gata6 controls the identity of the previously uncharacterized sebaceous duct (SD) lineage and identify the Gata6 downs...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature cell biology 2017-06, Vol.19 (6), p.603-613
Hauptverfasser:	Donati, Giacomo, Rognoni, Emanuel, Hiratsuka, Toru, Liakath-Ali, Kifayathullah, Hoste, Esther, Kar, Gozde, Kayikci, Melis, Russell, Roslin, Kretzschmar, Kai, Mulder, Klaas W., Teichmann, Sarah A., Watt, Fiona M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/31 13/51 14/19 38/23 38/39 38/77 631/532/2118/2438 631/532/2438 631/532/489 64/60 Animals Cancer Research Cell Biology Cell Dedifferentiation Cell Lineage Cell migration Cell Movement Cell Plasticity Cell Self Renewal Cells, Cultured Developmental Biology Disease Models, Animal Epidermis Epidermis - metabolism Epidermis - pathology Female GATA6 Transcription Factor - deficiency GATA6 Transcription Factor - genetics GATA6 Transcription Factor - metabolism Life Sciences Male Mice, Inbred C57BL Mice, Knockout Phenotype Positive Regulatory Domain I-Binding Factor 1 Progeny Sebaceous Glands - metabolism Sebaceous Glands - pathology Signal Transduction Stem Cells Stem Cells - metabolism Structure-function relationships Time Factors Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Wound Healing Wounds and Injuries - genetics Wounds and Injuries - metabolism Wounds and Injuries - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!